Gabapentin improves oral feeding in neurologically intact infants with abdominal disorders

Keliana L. O’Mara, Saleem Islam, Janice A. Taylor, Daniel Solomon, Michael D. Weiss

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Feeding intolerance, poor oral feeding skills, and retching are common symptoms seen in medically complex infants with a history of abdominal disorders and surgical interventions, such as gastrostomy tube placement and Nissen fundoplication. Visceral hyperalgesia may play a role in the underlying pathophysiology. We report the use of orally administered gabapentin in 3 infants with presumed visceral hyperalgesia presenting as poor tolerance of enteral and oral feeds. Retching and outward discomfort associated with feeds was resolved within 2 to 3 days of initiation of therapy. Full oral feeds were obtained in all 3 patients within 3 to 4 months of starting gabapentin without changing adjunctive medications or therapies. After attainment of full oral feeds, all patients were successfully weaned off gabapentin over a month, with no notable side effects, signs of withdrawal, or impact on ability to feed by mouth.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalJournal of Pediatric Pharmacology and Therapeutics
Issue number1
Publication statusPublished - 1 Jan 2018
Externally publishedYes


  • Gabapentin
  • Infant
  • Neonate
  • Oral feeding
  • Visceral hyperalgesia


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