TY - JOUR
T1 - Gastrin-releasing peptide receptor signaling in the integration of stress and memory
AU - Roesler, Rafael
AU - Kent, Pamela
AU - Luft, Tatiana
AU - Schwartsmann, Gilberto
AU - Merali, Zul
N1 - Funding Information:
This work was supported National Council for Scientific and Technological Development (CNPq; Grant numbers 303703/2009-1 and 484185/2012-8 to R.R); the National Institute for Translational Medicine (INCT-TM); the South American Office for Anticancer Drug Development (SOAD); the Canadian Institutes of Health Research (CIHR); and the Natural Science and Engineering Research Council of Canada (NSERC).
PY - 2014/7
Y1 - 2014/7
N2 - Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information.
AB - Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information.
KW - Bombesin receptor
KW - Fear memory
KW - Gastrin-releasing peptide
KW - Gastrin-releasing peptide receptor
KW - Memory consolidation
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=84901936062&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2013.08.013
DO - 10.1016/j.nlm.2013.08.013
M3 - Review article
C2 - 24001571
AN - SCOPUS:84901936062
SN - 1074-7427
VL - 112
SP - 44
EP - 52
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
ER -