Gastrin-releasing peptide receptor signaling in the integration of stress and memory

Rafael Roesler, Pamela Kent, Tatiana Luft, Gilberto Schwartsmann, Zul Merali

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalNeurobiology of Learning and Memory
Volume112
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • Bombesin receptor
  • Fear memory
  • Gastrin-releasing peptide
  • Gastrin-releasing peptide receptor
  • Memory consolidation
  • Stress

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