TY - JOUR
T1 - Gender differences in treatment outcomes among 15-49 year olds with smear-positive pulmonary tuberculosis in Kenya
AU - Kosgei, R. J.
AU - Sitienei, J. K.
AU - Kipruto, H.
AU - Kimenye, K.
AU - Gathara, D.
AU - Odawa, F. X.
AU - Gichangi, P.
AU - Callens, S.
AU - Temmerman, M.
AU - Sitienei, J. C.
AU - Kihara, A. B.
AU - Carter, E. J.
N1 - Publisher Copyright:
© 2015 The Union.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - OBJECTIVE: To determine gender differences in treatment outcomes among 15-49 year olds with smearpositive pulmonary tuberculosis (PTB) and factors associated with poor outcomes in Kenya. DESIGN: Retrospective descriptive cohort. RESULTS: Of 16 056 subjects analysed, 38% were female and 62% male. Females had a higher risk of poor treatment outcome than males (12% vs. 10%, P < 0.001; adjusted OR 1.29, 95%CI 1.16-1.44, P < 0.001). In the first multivariate model, restricting the analysis to human immunodeficiency virus (HIV) positive patients and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor outcome (OR 0.99, 95%CI 0.86-1.13, P=0.844). In the model restricted to HIV-negative patients, a nonsignificantly lower risk was found (OR 0.89, 95%CI 0.73-1.09, P = 0.267). In the second model, restricting analysis to patients on antiretroviral therapy (ART) and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor PTB treatment outcomes (OR 0.98, 95%CI 0.84-1.14, P = 0.792). In the model restricted to HIV-positive patients not on ART, a non-significantly higher risk was found (OR 1.15, 95%CI 0.79-1.67, P = 0.461). CONCLUSION: Females of reproductive age are likely to have poorer treatment outcomes than males. Among females, not commencing ART during anti-tuberculosis treatment seemed to be associated with poor outcomes.
AB - OBJECTIVE: To determine gender differences in treatment outcomes among 15-49 year olds with smearpositive pulmonary tuberculosis (PTB) and factors associated with poor outcomes in Kenya. DESIGN: Retrospective descriptive cohort. RESULTS: Of 16 056 subjects analysed, 38% were female and 62% male. Females had a higher risk of poor treatment outcome than males (12% vs. 10%, P < 0.001; adjusted OR 1.29, 95%CI 1.16-1.44, P < 0.001). In the first multivariate model, restricting the analysis to human immunodeficiency virus (HIV) positive patients and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor outcome (OR 0.99, 95%CI 0.86-1.13, P=0.844). In the model restricted to HIV-negative patients, a nonsignificantly lower risk was found (OR 0.89, 95%CI 0.73-1.09, P = 0.267). In the second model, restricting analysis to patients on antiretroviral therapy (ART) and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor PTB treatment outcomes (OR 0.98, 95%CI 0.84-1.14, P = 0.792). In the model restricted to HIV-positive patients not on ART, a non-significantly higher risk was found (OR 1.15, 95%CI 0.79-1.67, P = 0.461). CONCLUSION: Females of reproductive age are likely to have poorer treatment outcomes than males. Among females, not commencing ART during anti-tuberculosis treatment seemed to be associated with poor outcomes.
KW - HIV
KW - Reproductive age
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=84942790003&partnerID=8YFLogxK
U2 - 10.5588/ijtld.15.0070
DO - 10.5588/ijtld.15.0070
M3 - Article
C2 - 26459529
AN - SCOPUS:84942790003
SN - 1027-3719
VL - 19
SP - 1176
EP - 1181
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 10
ER -
