Gender differences in treatment outcomes among 15-49 year olds with smear-positive pulmonary tuberculosis in Kenya

R. J. Kosgei, J. K. Sitienei, H. Kipruto, K. Kimenye, D. Gathara, F. X. Odawa, P. Gichangi, S. Callens, M. Temmerman, J. C. Sitienei, A. B. Kihara, E. J. Carter

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7 Citations (Scopus)

Abstract

OBJECTIVE: To determine gender differences in treatment outcomes among 15-49 year olds with smearpositive pulmonary tuberculosis (PTB) and factors associated with poor outcomes in Kenya. DESIGN: Retrospective descriptive cohort. RESULTS: Of 16 056 subjects analysed, 38% were female and 62% male. Females had a higher risk of poor treatment outcome than males (12% vs. 10%, P < 0.001; adjusted OR 1.29, 95%CI 1.16-1.44, P < 0.001). In the first multivariate model, restricting the analysis to human immunodeficiency virus (HIV) positive patients and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor outcome (OR 0.99, 95%CI 0.86-1.13, P=0.844). In the model restricted to HIV-negative patients, a nonsignificantly lower risk was found (OR 0.89, 95%CI 0.73-1.09, P = 0.267). In the second model, restricting analysis to patients on antiretroviral therapy (ART) and adjusting for risk factors and clustering, females had a non-significantly lower risk of poor PTB treatment outcomes (OR 0.98, 95%CI 0.84-1.14, P = 0.792). In the model restricted to HIV-positive patients not on ART, a non-significantly higher risk was found (OR 1.15, 95%CI 0.79-1.67, P = 0.461). CONCLUSION: Females of reproductive age are likely to have poorer treatment outcomes than males. Among females, not commencing ART during anti-tuberculosis treatment seemed to be associated with poor outcomes.

Original languageEnglish
Pages (from-to)1176-1181
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume19
Issue number10
DOIs
Publication statusPublished - 1 Oct 2015
Externally publishedYes

Keywords

  • HIV
  • Reproductive age
  • Women

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