TY - JOUR
T1 - Global respiratory syncytial virus-associated mortality in young children (RSV GOLD)
T2 - a retrospective case series
AU - PERCH Study Group
AU - Scheltema, Nienke M.
AU - Gentile, Angela
AU - Lucion, Florencia
AU - Nokes, D. James
AU - Munywoki, Patrick K.
AU - Madhi, Shabir A.
AU - Groome, Michelle J.
AU - Cohen, Cheryl
AU - Moyes, Jocelyn
AU - Thorburn, Kentigern
AU - Thamthitiwat, Somsak
AU - Oshitani, Hitoshi
AU - Lupisan, Socorro P.
AU - Gordon, Aubree
AU - Sánchez, José F.
AU - O'Brien, Katherine L.
AU - Gessner, Bradford D.
AU - Sutanto, Agustinus
AU - Mejias, Asuncion
AU - Ramilo, Octavio
AU - Khuri-Bulos, Najwa
AU - Halasa, Natasha
AU - de-Paris, Fernanda
AU - Pires, Márcia Rosane
AU - Spaeder, Michael C.
AU - Paes, Bosco A.
AU - Simões, Eric A.F.
AU - Leung, Ting F.
AU - da Costa Oliveira, Maria Tereza
AU - de Freitas Lázaro Emediato, Carla Cecília
AU - Bassat, Quique
AU - Butt, Warwick
AU - Chi, Hsin
AU - Aamir, Uzma Bashir
AU - Ali, Asad
AU - Lucero, Marilla G.
AU - Fasce, Rodrigo A.
AU - Lopez, Olga
AU - Rath, Barbara A.
AU - Polack, Fernando P.
AU - Papenburg, Jesse
AU - Roglić, Srđan
AU - Ito, Hisato
AU - Goka, Edward A.
AU - Grobbee, Diederick E.
AU - Nair, Harish
AU - Bont, Louis J.
N1 - Funding Information:
The study was supported by the Bill & Melinda Gates Foundation (grant OPP1148988). We thank Mayuko Saito, Mwanajuma Ngama, Anne Bett, Cristiane Campos Monteiro, and Arjan Boer for their role in data collection.
Publisher Copyright:
© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
PY - 2017/10
Y1 - 2017/10
N2 - Background Respiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data. Methods In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. For the literature search, we searched PubMed for articles published up to Feb 3, 2015, using the key terms “RSV” “respiratory syncytial virus” or “respiratory syncytial viral” combined with “mortality” “fatality” “death” “died” “deaths” or “CFR” for articles published in English. We invited researchers and clinicians identified to participate between Nov 1, 2014, and Oct 31, 2015. We calculated descriptive statistics for all variables. Findings We studied 358 children with RSV-related in-hospital death from 23 countries across the world, with data contributed from 31 research groups. 117 (33%) children were from low-income or lower middle-income countries, 77 (22%) were from upper middle-income countries, and 164 (46%) were from high-income countries. 190 (53%) were male. Data for comorbidities were missing for some children in low-income and middle-income countries. Available data showed that comorbidities were present in at least 33 (28%) children from low-income or lower middle-income countries, 36 (47%) from upper middle-income countries, and 114 (70%) from high-income countries. Median age for RSV-related deaths was 5·0 months (IQR 2·3–11·0) in low-income or lower middle-income countries, 4·0 months (2·0–10·0) in upper middle-income countries, and 7·0 months (3·6–16·8) in high-income countries. Interpretation This study is the first large case series of children who died with community-acquired RSV infection. A substantial proportion of children with RSV-related death had comorbidities. Our results show that perinatal immunisation strategies for children aged younger than 6 months could have a substantial impact on RSV-related child mortality in low-income and middle-income countries. Funding Bill & Melinda Gates Foundation.
AB - Background Respiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data. Methods In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. For the literature search, we searched PubMed for articles published up to Feb 3, 2015, using the key terms “RSV” “respiratory syncytial virus” or “respiratory syncytial viral” combined with “mortality” “fatality” “death” “died” “deaths” or “CFR” for articles published in English. We invited researchers and clinicians identified to participate between Nov 1, 2014, and Oct 31, 2015. We calculated descriptive statistics for all variables. Findings We studied 358 children with RSV-related in-hospital death from 23 countries across the world, with data contributed from 31 research groups. 117 (33%) children were from low-income or lower middle-income countries, 77 (22%) were from upper middle-income countries, and 164 (46%) were from high-income countries. 190 (53%) were male. Data for comorbidities were missing for some children in low-income and middle-income countries. Available data showed that comorbidities were present in at least 33 (28%) children from low-income or lower middle-income countries, 36 (47%) from upper middle-income countries, and 114 (70%) from high-income countries. Median age for RSV-related deaths was 5·0 months (IQR 2·3–11·0) in low-income or lower middle-income countries, 4·0 months (2·0–10·0) in upper middle-income countries, and 7·0 months (3·6–16·8) in high-income countries. Interpretation This study is the first large case series of children who died with community-acquired RSV infection. A substantial proportion of children with RSV-related death had comorbidities. Our results show that perinatal immunisation strategies for children aged younger than 6 months could have a substantial impact on RSV-related child mortality in low-income and middle-income countries. Funding Bill & Melinda Gates Foundation.
UR - http://www.scopus.com/inward/record.url?scp=85031285432&partnerID=8YFLogxK
U2 - 10.1016/S2214-109X(17)30344-3
DO - 10.1016/S2214-109X(17)30344-3
M3 - Article
C2 - 28911764
AN - SCOPUS:85031285432
SN - 2214-109X
VL - 5
SP - e984-e991
JO - The Lancet Global Health
JF - The Lancet Global Health
IS - 10
ER -