Global think tank on the clinical considerations and management of lipoprotein(a): The top questions and answers regarding what clinicians need to know

Salim S. Virani, Marlys L. Koschinsky, Lisa Maher, Anurag Mehta, Carl E. Orringer, Raul D. Santos, Michael D. Shapiro, Joseph J. Saseen

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Evidence from Mendelian randomization studies suggest that lipoprotein(a) (Lp(a)) has a causal role in the development of atherosclerotic cardiovascular disease risk. However, guidelines and consensus statement recommendations vary regarding how clinicians should incorporate Lp(a) into patient care. To provide practical answers to key questions pertaining to Lp(a) that clinicians will find useful when assessing and treating patients, a global think tank was convened. Representatives from seven national and international stakeholder organizations answered questions that were focused on: Lp(a) measurement; ethnic, gender, and age considerations; factoring Lp(a) into risk assessment; and current and emerging treatment options for elevated Lp(a). This manuscript summarizes the finding from this global think tank. Areas requiring further investigation were identified, and the need to standardize reporting of Lp(a) levels to ensure harmonization and comparability across laboratories and research studies is emphasized.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalProgress in Cardiovascular Diseases
Volume73
DOIs
Publication statusPublished - 1 Jul 2022
Externally publishedYes

Keywords

  • Atherosclerotic cardiovascular disease
  • Hypercholesterolemia
  • Lipoprotein(a)
  • Low-density lipoprotein

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