Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria

Ruth Namazzi; Caroline Kazinga; Giselle Lima-Cooper; Claire Liepmann; Michael J. Goings; Olivia Bednarski; Marco Abreu; Tae Hwi Schwantes-An; Anthony Batte; Robert O. Opoka; Chandy C. John; Andrea L. Conroy

doi:10.1093/infdis/jiaf080

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria

Ruth Namazzi
, Caroline Kazinga
, Giselle Lima-Cooper
, Claire Liepmann
, Michael J. Goings
, Olivia Bednarski
, Marco Abreu
, Tae Hwi Schwantes-An
, Anthony Batte
, Robert O. Opoka
, Chandy C. John
, Andrea L. Conroy

Research output: Contribution to journal › Article › peer-review

Abstract

Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P =. 005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

Original language	English (US)
Pages (from-to)	127-132
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	232
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiaf080
Publication status	Published - 15 Jul 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AKI
G6PD
Severe malaria
intravascular hemolysis
sex differences

Access to Document

10.1093/infdis/jiaf080

Cite this

Namazzi, R., Kazinga, C., Lima-Cooper, G., Liepmann, C., Goings, M. J., Bednarski, O., Abreu, M., Schwantes-An, T. H., Batte, A., Opoka, R. O., John, C. C., & Conroy, A. L. (2025). Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria. Journal of Infectious Diseases, 232(1), 127-132. https://doi.org/10.1093/infdis/jiaf080

@article{51e50945a4aa45dcb90090150928d9a7,

title = "Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria",

abstract = "Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7\% among hemizygous male children and 2.4\% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95\% confidence interval, 1.33-4.93; P =. 005), adjusting for age, sex, site, nutritional status, and features of hemolysis.",

keywords = "AKI, G6PD, Severe malaria, intravascular hemolysis, sex differences",

author = "Ruth Namazzi and Caroline Kazinga and Giselle Lima-Cooper and Claire Liepmann and Goings, \{Michael J.\} and Olivia Bednarski and Marco Abreu and Schwantes-An, \{Tae Hwi\} and Anthony Batte and Opoka, \{Robert O.\} and John, \{Chandy C.\} and Conroy, \{Andrea L.\}",

year = "2025",

month = jul,

day = "15",

doi = "10.1093/infdis/jiaf080",

language = "English (US)",

volume = "232",

pages = "127--132",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "1",

}

Namazzi, R, Kazinga, C, Lima-Cooper, G, Liepmann, C, Goings, MJ, Bednarski, O, Abreu, M, Schwantes-An, TH, Batte, A, Opoka, RO, John, CC & Conroy, AL 2025, 'Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria', Journal of Infectious Diseases, vol. 232, no. 1, pp. 127-132. https://doi.org/10.1093/infdis/jiaf080

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria. / Namazzi, Ruth; Kazinga, Caroline; Lima-Cooper, Giselle et al.
In: Journal of Infectious Diseases, Vol. 232, No. 1, 15.07.2025, p. 127-132.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria

AU - Namazzi, Ruth

AU - Kazinga, Caroline

AU - Lima-Cooper, Giselle

AU - Liepmann, Claire

AU - Goings, Michael J.

AU - Bednarski, Olivia

AU - Abreu, Marco

AU - Schwantes-An, Tae Hwi

AU - Batte, Anthony

AU - Opoka, Robert O.

AU - John, Chandy C.

AU - Conroy, Andrea L.

PY - 2025/7/15

Y1 - 2025/7/15

N2 - Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P =. 005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

AB - Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P =. 005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

KW - AKI

KW - G6PD

KW - Severe malaria

KW - intravascular hemolysis

KW - sex differences

UR - https://www.scopus.com/pages/publications/105012296478

U2 - 10.1093/infdis/jiaf080

DO - 10.1093/infdis/jiaf080

M3 - Article

C2 - 39963714

AN - SCOPUS:105012296478

SN - 0022-1899

VL - 232

SP - 127

EP - 132

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 1

ER -

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated with Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children with Severe Malaria

Abstract

UN SDGs

Keywords

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