GOAL study: Clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice

Abdulqawi Al Mansari, Youssef Obeid, Najmul Islam, Mohammed Fariduddin, Ahmed Hassoun, Khier Djaballah, Mojtaba Malek, Dror Dicker, Tirthankar Chaudhury

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine.Research design and methods This was an international, multicenter, observational survey with 12-month follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries.Results Overall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m 2; Caucasian: 46.1%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (>10 vs 1 year, p<0.0001), lower baseline HbA1c (≥ 8.5% vs <7%, p<0.0001) and no intake of oral antidiabetic drug (OAD) (none vs 2, p=0.02) were predictive factors for achieving glycemic goal as targeted by the treating physician. Absolute changes in the mean HbA1c of '1.7% and '2% were observed from baseline to 6 and 12 months, respectively.Conclusions Along with some well-known predictive factors, this study suggested that early insulin regimen treatment initiation and/or intensification allowed patients to promote glycemic control.

Original languageEnglish
Article numbere000519
JournalBMJ Open Diabetes Research and Care
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • HbA1c
  • Insulin
  • Type 2 Diabetes
  • glycemic control

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