TY - JOUR
T1 - Haemorrhagic manifestations and utility of haematological parameters in dengue fever
T2 - A tertiary care centre experience at Karachi
AU - Ali, Natasha
AU - Usman, Mohammad
AU - Syed, Naveen
AU - Khurshid, Mohammad
N1 - Funding Information:
The y 2006 witnessed an outbreak of dengue fever in the city of Karachi. The presumptive clinical diagnosis of dengue fever was supported by deranged haematological parameters followed by confirmatory serological testing. Haemoconcentration, leucopenia and thrombocytopenia in the presence of haemorrhagic manifestations and strong clinical background can give important clues in reaching a diagnosis of dengue fever.
PY - 2007
Y1 - 2007
N2 - A retrospective observational study of dengue fever was performed, including 210 patients (male:female ratio 1.6:1, ages 6-74 y, mean 29.7 y) attending the Aga Khan University Hospital, Karachi from January 2001 to December 2006. All included patients proved dengue IgM antibody positive. Of these, 19 (9%) showed increased haemoglobin/haematocrit levels on admission which remained elevated in 4 (2.1%) at the time of discharge. 56 patients (26.6%) had leucopenia and neutropenia and 77.1% (161) had thrombocytopenia at the time of admission; 2.5% (5) and 16.7% (35) had deranged PT and APTT, respectively. Atypical lymphocytes were seen in 109 patients (52%). Platelet transfusion was given in 45 (22.1%) cases. The majority of patients were discharged without any adverse sequelae. The fatality rate was 3.3% (n = 7) and these patients died of dengue shock syndrome, while 196 (93.3%) recovered completely. Haematological parameters are an important clue and should be tested when a patient presents with symptoms suggestive of dengue fever.
AB - A retrospective observational study of dengue fever was performed, including 210 patients (male:female ratio 1.6:1, ages 6-74 y, mean 29.7 y) attending the Aga Khan University Hospital, Karachi from January 2001 to December 2006. All included patients proved dengue IgM antibody positive. Of these, 19 (9%) showed increased haemoglobin/haematocrit levels on admission which remained elevated in 4 (2.1%) at the time of discharge. 56 patients (26.6%) had leucopenia and neutropenia and 77.1% (161) had thrombocytopenia at the time of admission; 2.5% (5) and 16.7% (35) had deranged PT and APTT, respectively. Atypical lymphocytes were seen in 109 patients (52%). Platelet transfusion was given in 45 (22.1%) cases. The majority of patients were discharged without any adverse sequelae. The fatality rate was 3.3% (n = 7) and these patients died of dengue shock syndrome, while 196 (93.3%) recovered completely. Haematological parameters are an important clue and should be tested when a patient presents with symptoms suggestive of dengue fever.
UR - http://www.scopus.com/inward/record.url?scp=36348969415&partnerID=8YFLogxK
U2 - 10.1080/00365540701411492
DO - 10.1080/00365540701411492
M3 - Article
C2 - 17852892
AN - SCOPUS:36348969415
SN - 0036-5548
VL - 39
SP - 1025
EP - 1028
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 11-12
ER -
