HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2

Neeliyath A. Ramakrishnan; Marian J. Drescher; Khalid M. Khan; James S. Hatfield; Dennis G. Drescher

doi:10.1074/jbc.M112.375832

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2

Neeliyath A. Ramakrishnan, Marian J. Drescher, Khalid M. Khan, James S. Hatfield, Dennis G. Drescher

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Background: Protein-protein interaction between HCN1 and tip-link protocadherin 15CD3 suggests a role for HCN1 in hair-cell mechanotransduction. Results: HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. Conclusion: Alternate protein-protein interactions reflect separation of binding events for stereociliary proteins implicated in mechanotransduction. Significance: HCN1 is the only channel component identified as binding to a stereociliary tip-link protein.

Original language	English
Pages (from-to)	37628-37646
Number of pages	19
Journal	Journal of Biological Chemistry
Volume	287
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M112.375832
Publication status	Published - 2 Nov 2012
Externally published	Yes

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title = "HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2",

abstract = "Background: Protein-protein interaction between HCN1 and tip-link protocadherin 15CD3 suggests a role for HCN1 in hair-cell mechanotransduction. Results: HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. Conclusion: Alternate protein-protein interactions reflect separation of binding events for stereociliary proteins implicated in mechanotransduction. Significance: HCN1 is the only channel component identified as binding to a stereociliary tip-link protein.",

author = "Ramakrishnan, {Neeliyath A.} and Drescher, {Marian J.} and Khan, {Khalid M.} and Hatfield, {James S.} and Drescher, {Dennis G.}",

year = "2012",

month = nov,

day = "2",

doi = "10.1074/jbc.M112.375832",

language = "English",

volume = "287",

pages = "37628--37646",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "Elsevier Inc.",

number = "45",

}

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2. / Ramakrishnan, Neeliyath A.; Drescher, Marian J.; Khan, Khalid M. et al.
In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 37628-37646.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - HCN1 and HCN2 proteins are expressed in cochlear hair cells

T2 - HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2

AU - Ramakrishnan, Neeliyath A.

AU - Drescher, Marian J.

AU - Khan, Khalid M.

AU - Hatfield, James S.

AU - Drescher, Dennis G.

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Background: Protein-protein interaction between HCN1 and tip-link protocadherin 15CD3 suggests a role for HCN1 in hair-cell mechanotransduction. Results: HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. Conclusion: Alternate protein-protein interactions reflect separation of binding events for stereociliary proteins implicated in mechanotransduction. Significance: HCN1 is the only channel component identified as binding to a stereociliary tip-link protein.

AB - Background: Protein-protein interaction between HCN1 and tip-link protocadherin 15CD3 suggests a role for HCN1 in hair-cell mechanotransduction. Results: HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. Conclusion: Alternate protein-protein interactions reflect separation of binding events for stereociliary proteins implicated in mechanotransduction. Significance: HCN1 is the only channel component identified as binding to a stereociliary tip-link protein.

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DO - 10.1074/jbc.M112.375832

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SN - 0021-9258

VL - 287

SP - 37628

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JO - Journal of Biological Chemistry

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IS - 45

ER -

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2

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