Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception

Sikolia Z. Wanyonyi; William R. Stones; Evan Sequeira

doi:10.1016/j.contraception.2011.05.022

Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception

Sikolia Z. Wanyonyi
, William R. Stones
, Evan Sequeira

Medical College, East Africa

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Depot medroxyprogesterone acetate (DMPA) may have other noncontraceptive effects that could impact on the quality of life. The objective of this study was to assess the health-related quality of life changes associated with the use of DMPA for contraception. Study Design: A prospective, observational study using the Short Form-36 quality of life questionnaire. Results: After 6 months of use, the participants had an improved physical summary score, mean change [5.64 (95% confidence interval [CI], 1.87-9.4), p=.054]. There was no significant change in sexual function [5.33 (95% CI, -2.15 to 12.81), p=.0858] and mental summary score [-0.51 (95% CI, -1.90 to 2.92), p=.432]. The main side effect of DMPA was menstrual irregularity (32.5%); 17.2% of the participants found amenorrhea desirable. Conclusion: Besides its contraceptive efficacy, DMPA is associated with an improvement in perceived physical health with no apparent adverse effect on mental health and sexual function.

Original language	English (UK)
Pages (from-to)	e17-e22
Journal	Contraception
Volume	84
Issue number	5
DOIs	https://doi.org/10.1016/j.contraception.2011.05.022
Publication status	Published - Nov 2011

Keywords

Contraception
Depo medroxyprogesterone acetate
Health-related quality of life
SF-36

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.contraception.2011.05.022

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@article{5e139fc261604bff8621cf79e37fcb3d,

title = "Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception",

abstract = "Background: Depot medroxyprogesterone acetate (DMPA) may have other noncontraceptive effects that could impact on the quality of life. The objective of this study was to assess the health-related quality of life changes associated with the use of DMPA for contraception. Study Design: A prospective, observational study using the Short Form-36 quality of life questionnaire. Results: After 6 months of use, the participants had an improved physical summary score, mean change [5.64 (95\% confidence interval [CI], 1.87-9.4), p=.054]. There was no significant change in sexual function [5.33 (95\% CI, -2.15 to 12.81), p=.0858] and mental summary score [-0.51 (95\% CI, -1.90 to 2.92), p=.432]. The main side effect of DMPA was menstrual irregularity (32.5\%); 17.2\% of the participants found amenorrhea desirable. Conclusion: Besides its contraceptive efficacy, DMPA is associated with an improvement in perceived physical health with no apparent adverse effect on mental health and sexual function.",

keywords = "Contraception, Depo medroxyprogesterone acetate, Health-related quality of life, SF-36",

author = "Wanyonyi, \{Sikolia Z.\} and Stones, \{William R.\} and Evan Sequeira",

note = "Funding Information: Funding: We received funding from the Aga Khan University research grant for postgraduate medical education. ",

year = "2011",

month = nov,

doi = "10.1016/j.contraception.2011.05.022",

language = "English (UK)",

volume = "84",

pages = "e17--e22",

journal = "Contraception",

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number = "5",

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T1 - Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception

AU - Wanyonyi, Sikolia Z.

AU - Stones, William R.

AU - Sequeira, Evan

N1 - Funding Information: Funding: We received funding from the Aga Khan University research grant for postgraduate medical education.

PY - 2011/11

Y1 - 2011/11

N2 - Background: Depot medroxyprogesterone acetate (DMPA) may have other noncontraceptive effects that could impact on the quality of life. The objective of this study was to assess the health-related quality of life changes associated with the use of DMPA for contraception. Study Design: A prospective, observational study using the Short Form-36 quality of life questionnaire. Results: After 6 months of use, the participants had an improved physical summary score, mean change [5.64 (95% confidence interval [CI], 1.87-9.4), p=.054]. There was no significant change in sexual function [5.33 (95% CI, -2.15 to 12.81), p=.0858] and mental summary score [-0.51 (95% CI, -1.90 to 2.92), p=.432]. The main side effect of DMPA was menstrual irregularity (32.5%); 17.2% of the participants found amenorrhea desirable. Conclusion: Besides its contraceptive efficacy, DMPA is associated with an improvement in perceived physical health with no apparent adverse effect on mental health and sexual function.

AB - Background: Depot medroxyprogesterone acetate (DMPA) may have other noncontraceptive effects that could impact on the quality of life. The objective of this study was to assess the health-related quality of life changes associated with the use of DMPA for contraception. Study Design: A prospective, observational study using the Short Form-36 quality of life questionnaire. Results: After 6 months of use, the participants had an improved physical summary score, mean change [5.64 (95% confidence interval [CI], 1.87-9.4), p=.054]. There was no significant change in sexual function [5.33 (95% CI, -2.15 to 12.81), p=.0858] and mental summary score [-0.51 (95% CI, -1.90 to 2.92), p=.432]. The main side effect of DMPA was menstrual irregularity (32.5%); 17.2% of the participants found amenorrhea desirable. Conclusion: Besides its contraceptive efficacy, DMPA is associated with an improvement in perceived physical health with no apparent adverse effect on mental health and sexual function.

KW - Contraception

KW - Depo medroxyprogesterone acetate

KW - Health-related quality of life

KW - SF-36

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DO - 10.1016/j.contraception.2011.05.022

M3 - Article

C2 - 22018133

AN - SCOPUS:80054920198

SN - 0010-7824

VL - 84

SP - e17-e22

JO - Contraception

JF - Contraception

IS - 5

ER -

Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception

Abstract

Keywords

UN SDGs

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