TY - JOUR
T1 - Heartburn’s Hidden Impact
T2 - A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor
AU - Gries, Jacob J.
AU - Chen, Bing
AU - Virani, Salim S.
AU - Virk, Hafeez Ul Hassan
AU - Jneid, Hani
AU - Krittanawong, Chayakrit
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12
Y1 - 2023/12
N2 - Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD.
AB - Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD.
KW - atherosclerosis
KW - cardiovascular disease (CVD)
KW - coronary artery disease (CAD)
KW - gastroesophageal reflux disease (GERD)
KW - myocardial infarction (MI)
KW - proton pump inhibitor (PPI)
UR - http://www.scopus.com/inward/record.url?scp=85179350576&partnerID=8YFLogxK
U2 - 10.3390/jcm12237400
DO - 10.3390/jcm12237400
M3 - Review article
AN - SCOPUS:85179350576
SN - 2077-0383
VL - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 23
M1 - 7400
ER -