TY - JOUR
T1 - Helicobacter pylori colonization in infants in a periurban community in Karachi, Pakistan
AU - Nizami, Shaikh Qamaruddin
AU - Bhutta, Zulfiqar Ahmed
AU - Weaver, Lawrence
AU - Preston, Tom
PY - 2005/8
Y1 - 2005/8
N2 - Background: The prevalence and incidence of Helicobacter pylori in children in Pakistan is not known. Objectives: To measure the prevalence and age of acquisition of Helicobacter pylori infection/colonization in infants in a peri-urban community in Karachi, Pakistan. Setting: Field based epidemiologic study in a peri-urban community in Karachi, Pakistan. Methods: Infants aged 1 to 3 months were recruited from a birth cohort from the community. 13C-urea breath test (13C-UBT) was performed on recruitment, and the test was repeated at 2, 3, 6, and 9 months of age. Results: One hundred forty-eight infants were recruited and had 13C-UBT on 319 occasions over a period of 2 years. Two hundred thirty-one = (72%) tests were positive: 80% (49/61) infants at 1 month of age, 79% (33/42) at 2 month of age, 76% (92/121) at 3 month of age, 58% (37/64) at 6 months of age, and 67% (20/30) at 9 months of age. Conclusions: The study reveals an early colonization/infection of infants and a high prevalence of Helicobacter pylori in a periurban community in Karachi, Pakistan.
AB - Background: The prevalence and incidence of Helicobacter pylori in children in Pakistan is not known. Objectives: To measure the prevalence and age of acquisition of Helicobacter pylori infection/colonization in infants in a peri-urban community in Karachi, Pakistan. Setting: Field based epidemiologic study in a peri-urban community in Karachi, Pakistan. Methods: Infants aged 1 to 3 months were recruited from a birth cohort from the community. 13C-urea breath test (13C-UBT) was performed on recruitment, and the test was repeated at 2, 3, 6, and 9 months of age. Results: One hundred forty-eight infants were recruited and had 13C-UBT on 319 occasions over a period of 2 years. Two hundred thirty-one = (72%) tests were positive: 80% (49/61) infants at 1 month of age, 79% (33/42) at 2 month of age, 76% (92/121) at 3 month of age, 58% (37/64) at 6 months of age, and 67% (20/30) at 9 months of age. Conclusions: The study reveals an early colonization/infection of infants and a high prevalence of Helicobacter pylori in a periurban community in Karachi, Pakistan.
KW - C-UBT
KW - Helicobacter pylori
KW - Infants
UR - http://www.scopus.com/inward/record.url?scp=23244462049&partnerID=8YFLogxK
U2 - 10.1097/01.mpg.0000172263.12920.6b
DO - 10.1097/01.mpg.0000172263.12920.6b
M3 - Article
C2 - 16056098
AN - SCOPUS:23244462049
SN - 0277-2116
VL - 41
SP - 191
EP - 194
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 2
ER -