Hepatic dysfunction in paediatric typhoidal salmonellosis

Z. A. Bhutta, S. H. Naqvi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Although hepatic dysfunction has been described among adults with typhoid, there are few reports of significant hepatic functional impairment in children with typhoid. Of 435 children with culture-proven typhoid seen at the Aga Khan University Hospital, hepatomegaly was noted in 125 (29%) and isolated right hypochondrial tenderness in three (7%). Liver function tests performed on 156 of these children were normal in 121 (78%) and showed significant hepatic dysfunction in 35 (22%). Patients with significant hepatic dysfunction were more toxic (p < 0.001) at presentation and had higher mortality (p < 0.002) than those with normal liver function. Two children presented with a picture of fulminant hepatic failure with fatal outcome.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalAnnals of Tropical Paediatrics
Issue number3
Publication statusPublished - 1991


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