Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

Gary M. Clifford; Tim Waterboer; Bolormaa Dondog; You Lin Qiao; Dimitri Kordzaia; Doudja Hammouda; Namory Keita; Nahid Khodakarami [Unknown]; Syed Ahsan Ali; Ang Tshering Sherpa; Witold Zatonski

Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

Gary M. Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami [Unknown], Syed Ahsan Ali, Ang Tshering Sherpa, Witold Zatonski

Section of Internal Medicine, Department of Medicine, Medical College, Pakistan

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Abstract

BACKGROUND:

New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC).

METHODS:

Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology.

RESULTS:

Crude HCV prevalence ranged from 17.4% in Mongolia to 0.0% in Iran. In a pooled model adjusted by age and country, in which associations with risk factors were not statistically heterogeneous across countries, the only significant determinants of HCV positivity were age (prevalence ratio for ≥45 versus CONCLUSIONS:

HCV prevalence varies enormously in women worldwide. Medical interventions/hospitalizations linked to childbirth may have represented a route of HCV transmission, but not sexual intercourse. Combining dried blood spot collection with high-throughput HCV assays can facilitate seroepidemiological studies in LMIC where data is otherwise scarce

Original language	Undefined/Unknown
Journal	Department of Surgery
Publication status	Published - 1 Feb 2017

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Hepatitis C virus seroprevalence in the general female population

http://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/527

Cite this

@article{a082625ce126470fbfd657a79480c0b9,

title = "Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa",

abstract = "Abstract BACKGROUND: New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC). METHODS: Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology. RESULTS: Crude HCV prevalence ranged from 17.4\% in Mongolia to 0.0\% in Iran. In a pooled model adjusted by age and country, in which associations with risk factors were not statistically heterogeneous across countries, the only significant determinants of HCV positivity were age (prevalence ratio for ≥45 versus CONCLUSIONS: HCV prevalence varies enormously in women worldwide. Medical interventions/hospitalizations linked to childbirth may have represented a route of HCV transmission, but not sexual intercourse. Combining dried blood spot collection with high-throughput HCV assays can facilitate seroepidemiological studies in LMIC where data is otherwise scarce",

author = "Clifford, \{Gary M.\} and Tim Waterboer and Bolormaa Dondog and Qiao, \{You Lin\} and Dimitri Kordzaia and Doudja Hammouda and Namory Keita and [Unknown], \{Nahid Khodakarami\} and Ali, \{Syed Ahsan\} and Sherpa, \{Ang Tshering\} and Witold Zatonski",

year = "2017",

month = feb,

day = "1",

language = "Undefined/Unknown",

journal = "Department of Surgery",

}

TY - JOUR

T1 - Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

AU - Clifford, Gary M.

AU - Waterboer, Tim

AU - Dondog, Bolormaa

AU - Qiao, You Lin

AU - Kordzaia, Dimitri

AU - Hammouda, Doudja

AU - Keita, Namory

AU - [Unknown], Nahid Khodakarami

AU - Ali, Syed Ahsan

AU - Sherpa, Ang Tshering

AU - Zatonski, Witold

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Abstract BACKGROUND: New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC). METHODS: Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology. RESULTS: Crude HCV prevalence ranged from 17.4% in Mongolia to 0.0% in Iran. In a pooled model adjusted by age and country, in which associations with risk factors were not statistically heterogeneous across countries, the only significant determinants of HCV positivity were age (prevalence ratio for ≥45 versus CONCLUSIONS: HCV prevalence varies enormously in women worldwide. Medical interventions/hospitalizations linked to childbirth may have represented a route of HCV transmission, but not sexual intercourse. Combining dried blood spot collection with high-throughput HCV assays can facilitate seroepidemiological studies in LMIC where data is otherwise scarce

AB - Abstract BACKGROUND: New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC). METHODS: Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology. RESULTS: Crude HCV prevalence ranged from 17.4% in Mongolia to 0.0% in Iran. In a pooled model adjusted by age and country, in which associations with risk factors were not statistically heterogeneous across countries, the only significant determinants of HCV positivity were age (prevalence ratio for ≥45 versus CONCLUSIONS: HCV prevalence varies enormously in women worldwide. Medical interventions/hospitalizations linked to childbirth may have represented a route of HCV transmission, but not sexual intercourse. Combining dried blood spot collection with high-throughput HCV assays can facilitate seroepidemiological studies in LMIC where data is otherwise scarce

M3 - Article

JO - Department of Surgery

JF - Department of Surgery

ER -