Higher IL-10 levels are associated with less effective clearance of Plasmodium falciparum parasites

E. Hugosson, S. M. Montgomery, Z. Premji, M. Troye-Blomberg, A. Björkman

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57 Citations (Scopus)

Abstract

The implications of high levels of the immune regulatory cytokine IL-10 in Plasmodium falciparum malaria are unclear. IL-10 may down-regulate pro-inflammatory responses and also exacerbate disease by inhibiting anti-parasitic immune functions. To study possible inhibiting effects on parasite clearance, IL-10 plasma levels were determined in 104 Tanzanian children, 1 to 4 years old, with acute uncomplicated P. falciparum malaria, and analysed for association with parasite densities during 3 days of anti-malarial treatment. Higher baseline IL-10 plasma levels were associated with statistically significantly higher parasite densities after 24, 48 and 72 h of treatment. These associations could not be explained by differences in initial parasitaemia, temperature, age, sex or type of treatment. Induction of high IL-10 production might be a direct or indirect mechanism whereby the parasite evades the immune response.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalParasite Immunology
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 2004
Externally publishedYes

Keywords

  • IL-10
  • Malaria
  • Parasitaemia
  • Parasite density
  • Plasmodium falciparum

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