Histological pattern of central nervous system neoplasms

Z. Ahmed, S. Muzaffar, N. Kayani, S. Pervez, A. S. Husainy, S. H. Hasan

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Objective: To see in a large series of patients the histological pattern of CNS neoplasms and to provide a comprehensive data about the frequency of CNS neoplasms in Pakistani patients and to give a clearer idea about their prevalence. Method: Retrospective study of all consecutive cases of CNS neoplasms diagnosed at The Aga Khan University Hospital (AKUH) between 1st January , 1994 and 31st December , 1999. Setting: The section of Histopathology , AKUH, Karachi. Observation: Our series included a large number of cases i.e., 1110 . There are very few local studies on CNS tumours and none so large . Our data was correlated with published Western and Pakistani data . Glial tumours were the commonest primary CNS neoplasms followed by meningiomas . Among glial tumours , astrocytomas comprised the largest group and the majority were high grade (III and IV) astrocytomas. Percentages of anaplastic oligodendrogliomas and ependymomas were also significant. Male to female ratio was 1.6:1 . However, meningiomas were more common in females. Almost half of the CNS tumours in patients 15 years or younger were in the posterior cranial fossa . Metastatic tumours were much lower as compared to the West. Conclusion: Except for the high percentages of anaplastic oligodendrogliomas and ependymomas and the low percentage of metastatic tumours, most of our findings roughly correspond with the published data .

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalJournal of the Pakistan Medical Association
Issue number4
Publication statusPublished - Apr 2001


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