Histopathological effects on stomach, liver and kidney associated with Cedrus deodara root oil in ulcer induced rats (Wistar strain)

Kiran Mashaal, Rehana Perveen, Zubia Zia, Syed Muhammad Mahmood, Khurram Minhas, Sadaf Ibrahim, Syed Naim Ul Hasan Naqvi, Hira Naeem

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1 Citation (Scopus)


Cedrus deodara have been used traditionally in ayurvedic system against peptic ulcer. Present work is concerned with the determination of histopathological effects in ethanol induced ulcer on rats (Wistar Strain) treated with Cedrus deodara root oil at a dose of 200mg/kg and comparison of its antiulcer activity against control, positive control and standard anti-ulcer drug (Omeprazole). The aim was to find out the antiulcer effect of Cedrus deodara root oil and to observe histopathology of liver, kidney as well. 120 Albino rats were taken and divided into four groups i.e. A, B, C and D designated as control, positive control, standard and treated groups respectively. Normal and intact general architecture of mucosa and submucosa layers of stomach observed. No significant changes observed in thickness of epithelium, no inflammatory cells were present on the mucosa and submucosal layer and gastric glands were normal. Liver of albino rats, showed no dilation and congestion in central as well as portal vein. Kidney of albino rats exhibited no shrinkage in glomeruli, no congested and dilated renal corpuscles, neither hemolysis nor congested and dilated renal tubules were seen. It is concluded that C. deodara root oil has anti-ulcer properties without effecting kidney and liver tissues.

Original languageEnglish
Pages (from-to)2483-2488
Number of pages6
JournalPakistan Journal of Pharmaceutical Sciences
Issue number6
Publication statusPublished - Nov 2020


  • Anti-ulcer
  • Cedrus deodara
  • Histopathological
  • Omeprazole
  • Peptic ulcer


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