Histopathology of Bone and Soft Tissue

Bone and soft tissue pathology is considered to be one of the most challenging areas of diagnostic pathology. It requires not only radiologic films at hand but also frequent use of ancillary tests like special and immunohistochemical (IHC) stains. Many chromosomal translocations and other chromosomal abnormalities are hallmark of several of these tumours which require molecular genetic testing usually by using techniques as FISH. Hence an attempt is made to encompass not only light microscopic features and pattern analysis but also judicious use of special and IHC stains as well as FISH to describe and diagnose a distinct entity compatible with clinical presentation and radiologic findings.