Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Ruth Namazzi; Caitlin Bond; Andrea L. Conroy; Dibyadyuti Datta; Abner Tagoola; Michael J. Goings; Jeong Hoon Jang; Russell E. Ware; Robert Opoka; Chandy C. John

doi:10.1182/blood.2023021575

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Ruth Namazzi, Caitlin Bond, Andrea L. Conroy, Dibyadyuti Datta, Abner Tagoola, Michael J. Goings, Jeong Hoon Jang, Russell E. Ware, Robert Opoka, Chandy C. John

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

Original language	English
Pages (from-to)	1425-1428
Number of pages	4
Journal	Blood
Volume	143
Issue number	14
DOIs	https://doi.org/10.1182/blood.2023021575
Publication status	Published - 4 Apr 2024
Externally published	Yes

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10.1182/blood.2023021575

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title = "Hydroxyurea reduces infections in children with sickle cell anemia in Uganda",

abstract = "After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).",

author = "Ruth Namazzi and Caitlin Bond and Conroy, {Andrea L.} and Dibyadyuti Datta and Abner Tagoola and Goings, {Michael J.} and Jang, {Jeong Hoon} and Ware, {Russell E.} and Robert Opoka and John, {Chandy C.}",

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doi = "10.1182/blood.2023021575",

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T1 - Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

AU - Namazzi, Ruth

AU - Bond, Caitlin

AU - Conroy, Andrea L.

AU - Datta, Dibyadyuti

AU - Tagoola, Abner

AU - Goings, Michael J.

AU - Jang, Jeong Hoon

AU - Ware, Russell E.

AU - Opoka, Robert

AU - John, Chandy C.

PY - 2024/4/4

Y1 - 2024/4/4

N2 - After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

AB - After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

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U2 - 10.1182/blood.2023021575

DO - 10.1182/blood.2023021575

M3 - Article

C2 - 38169476

AN - SCOPUS:85184080855

SN - 0006-4971

VL - 143

SP - 1425

EP - 1428

JO - Blood

JF - Blood

IS - 14

ER -

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Abstract

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