Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Ruth Namazzi; Caitlin Bond; Andrea L. Conroy; Dibyadyuti Datta; Abner Tagoola; Michael J. Goings; Jeong Hoon Jang; Russell E. Ware; Robert Opoka; Chandy C. John

doi:10.1182/blood.2023021575

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Ruth Namazzi
, Caitlin Bond
, Andrea L. Conroy
, Dibyadyuti Datta
, Abner Tagoola
, Michael J. Goings
, Jeong Hoon Jang
, Russell E. Ware
, Robert Opoka
, Chandy C. John

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

Original language	English (US)
Pages (from-to)	1425-1428
Number of pages	4
Journal	Blood
Volume	143
Issue number	14
DOIs	https://doi.org/10.1182/blood.2023021575
Publication status	Published - 4 Apr 2024
Externally published	Yes

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10.1182/blood.2023021575

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title = "Hydroxyurea reduces infections in children with sickle cell anemia in Uganda",

abstract = "After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60\% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95\% confidence interval, 0.29-0.54]; P < .001).",

author = "Ruth Namazzi and Caitlin Bond and Conroy, \{Andrea L.\} and Dibyadyuti Datta and Abner Tagoola and Goings, \{Michael J.\} and Jang, \{Jeong Hoon\} and Ware, \{Russell E.\} and Robert Opoka and John, \{Chandy C.\}",

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year = "2024",

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doi = "10.1182/blood.2023021575",

language = "English (US)",

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journal = "Blood",

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TY - JOUR

T1 - Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

AU - Namazzi, Ruth

AU - Bond, Caitlin

AU - Conroy, Andrea L.

AU - Datta, Dibyadyuti

AU - Tagoola, Abner

AU - Goings, Michael J.

AU - Jang, Jeong Hoon

AU - Ware, Russell E.

AU - Opoka, Robert

AU - John, Chandy C.

PY - 2024/4/4

Y1 - 2024/4/4

N2 - After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

AB - After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

UR - https://www.scopus.com/pages/publications/85184080855

U2 - 10.1182/blood.2023021575

DO - 10.1182/blood.2023021575

M3 - Article

C2 - 38169476

AN - SCOPUS:85184080855

SN - 0006-4971

VL - 143

SP - 1425

EP - 1428

JO - Blood

JF - Blood

IS - 14

ER -

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Abstract

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