Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

Sung-Jae Cha, Xiang Yu, Brian Gregory, Yong Seok Lee, Tomoko Ishino, Robert Opoka, Chandy John, Marcelo Jacobs Loreno

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Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.

Original languageUndefined/Unknown
JournalPaediatrics and Child Health, East Africa
Publication statusPublished - 1 Feb 2022

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