Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

Sung-Jae Cha; Xiang Yu; Brian Gregory; Yong Seok Lee; Tomoko Ishino; Robert Opoka; Chandy John; Marcelo Jacobs Loreno

Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

Sung-Jae Cha, Xiang Yu, Brian Gregory, Yong Seok Lee, Tomoko Ishino, Robert Opoka, Chandy John, Marcelo Jacobs Loreno

Medical College, East Africa

Research output: Contribution to journal › Article

Abstract

Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
Publication status	Published - 1 Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/288

Cite this

@article{e8eef79ed176497aa0e5ae441bfb3dd5,

title = "Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways",

abstract = "Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.",

author = "Sung-Jae Cha and Xiang Yu and Brian Gregory and Lee, {Yong Seok} and Tomoko Ishino and Robert Opoka and Chandy John and Loreno, {Marcelo Jacobs}",

year = "2022",

month = feb,

day = "1",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

}

TY - JOUR

T1 - Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

AU - Cha, Sung-Jae

AU - Yu, Xiang

AU - Gregory, Brian

AU - Lee, Yong Seok

AU - Ishino, Tomoko

AU - Opoka, Robert

AU - John, Chandy

AU - Loreno, Marcelo Jacobs

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.

AB - Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

ER -