Immunogenicity of 10 and 20 μg hepatitis B vaccine in a two-dose schedule

Najib Ul-Haq, Syed S. Hasnain, Muhammad Umar, Zaigham Abbas, Carmen Valenzuela-Silva, Pedro Lopez-Saura

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Healthy subjects (15-50 years old) were randomised to receive, intramuscularly, 10 or 20μg of a yeast-derived recombinant hepatitis B vaccine (Heberbiovac HB) on a two-dose (0-1) schedule. Anti-hepatitis B surface antigen antibodies (HBsAb) were determined at 2, 3 and 6 months. Twenty micrograms immunisation yielded 96.3% seroprotection (HBsAb >10IU/l) at t=3, which persisted to 97.2% at t=6. The 10μg group resulted in 87.4% seroprotection at t=3 and 81% at t=6, but reached >95% among subjects <21 years old, both at t=3 and 6. It is concluded that the vaccine used is highly immunogenic and the two-dose 20μg immunisation can be used in all age groups and 10μg in subjects up to 20 years. These schedules can result in significantly better compliance and cost-effectiveness of the vaccination programs.

Original languageEnglish
Pages (from-to)3179-3185
Number of pages7
Issue number23
Publication statusPublished - 4 Jul 2003
Externally publishedYes


  • Recombinant hepatitis B vaccine
  • Two-doses


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