Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: Clinical and prognostic significance

Atif Ali Hashmi, Zubaida Fida Hussain, Shumaila Kanwal Hashmi, Muhammad Irfan, Erum Yousuf Khan, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Objective: Immunohistochemical over expression of p53 is considered as a marker of poor prognosis in many cancers. Therefore, we aimed to evaluate immunohistochemical overexpression of p53 in 121 cases of head and neck Squamous cell carcinoma and its association with various clinicopathologic features and survival. Results: Total 66.1% (80 cases) expressed positive p53 expression, 34% (29 cases) revealed no p53 expression, while focal positive p53 expression was noted in 9.9% (12 Cases). Moreover, high p53 expression (> 70%) was noted in 26.4% (32 cases), while 19% (23 cases) showed 51-70% p53 expression. On the basis of intensity of p53 staining; strong p53 expression was noted in 39.7% (48 cases), while 24.8% (30 cases) and 10.7% (13 cases) revealed intermediate and weak p53 expression respectively. Significant association of p53 intensity of expression with extranodal extension and higher tumor grade (grades II and III) was noted. p53 is useful prognostic biomarker in head and neck Squamous cell carcinoma and therefore we suggest that more large scale studies are needed to evaluate its prognostic significance in our population.

Original languageEnglish
Article number433
JournalBMC Research Notes
Volume11
Issue number1
DOIs
Publication statusPublished - 3 Jul 2018
Externally publishedYes

Keywords

  • Areca nut
  • Gutka
  • Head and Squamous cell carcinoma
  • Oropharyngeal Squamous cell carcinoma
  • p53

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