Abstract
Dihydrofolate reductase from L1210 leukemia cells which are sensitive and resistant to methotrexate has the same physical and kinetic properties and immunoreactivity with a guinea pig antiserum raised to the enzyme purified from the methotrexate resistant strain. However, a chicken antiserum to dihydrofolate reductase from methotrexate sensitive L1210 cells has greater affinity for the homologous enzyme than for the enzyme from the MTX resistant cells indicating that there is some antigenic difference in these molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 98-102 |
| Number of pages | 5 |
| Journal | Experimental Biology and Medicine |
| Volume | 180 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1985 |
| Externally published | Yes |