TY - JOUR
T1 - Impact of fine particulate pollution exposures on respiratory health in a megacity of Pakistan
AU - Lin, Qiaoxuan
AU - Lin, Ziqiang
AU - Lin, Shao
AU - Fatmi, Zafar
AU - Rizvi, Nadeem A.
AU - Hussain, Mirza M.
AU - Siddique, Azhar
AU - Moyebi, Omosehin D.
AU - Carpenter, David O.
AU - Khwaja, Haider A.
N1 - Publisher Copyright:
© 2024 Turkish National Committee for Air Pollution Research and Control
PY - 2024/12
Y1 - 2024/12
N2 - Air pollution poses a substantial barrier to global environmental sustainability and citizen well-being. However, there is a lack of research that specifically examines the effects of short-term exposure to PM2.5 and its components on health outcomes in developing nations in Asia, regions often cited as having some of the most severe urban air quality issues globally. The present study evaluated the associations between PM2.5 components and hospital admissions (HA) and emergency room visits (ERV) for respiratory diseases in the megacity of Karachi, Pakistan. We measured PM2.5 constituents, including black carbon (BC) and ionic species (sulfate - SO42−; nitrate - NO3−; and ammonium - NH4+) at two sites (August 2008 to August 2009) in Karachi. The HA and ERV, respiratory disease outcome data, were collected from three local, large tertiary care hospitals. We assessed the lag structure of excess risk (ER) of the pollutants-outcomes association (0–6 single and cumulative lag days) using time-series quasi-Poisson models after adjusting for temperature, humidity, and day of the week. Among a total 13,827 patients, the highest ERs for all respiratory urgent care use (UCU) were observed for PM2.5 (10.3, 95% CI: 2.59%-18.59), NH4+ (9.58%, 95% CI: 1.50%–18.30%), air quality index (9.11%, 95%CI: 2.54%–16.09%) and SO42− (7.26%, 95% CI: 1.03%–13.87%) within 0–4 lag days. Additionally, patients with chronic obstructive pulmonary disease (COPD), tuberculosis (TB), or other pulmonary diseases and older or male patients were more vulnerable to these pollutants. This first study in Pakistan found that PM2.5 and its constituents were associated with respiratory HAs and ERVs for the inhabitants of the megacity of Karachi. These associations varied by different PM constituents, disease subtypes, age, and gender. Our results provide important information to policymakers for developing regulations for improving air quality and public health. Further studies are urgently needed in other developing countries to disentangle the air pollution health effects.
AB - Air pollution poses a substantial barrier to global environmental sustainability and citizen well-being. However, there is a lack of research that specifically examines the effects of short-term exposure to PM2.5 and its components on health outcomes in developing nations in Asia, regions often cited as having some of the most severe urban air quality issues globally. The present study evaluated the associations between PM2.5 components and hospital admissions (HA) and emergency room visits (ERV) for respiratory diseases in the megacity of Karachi, Pakistan. We measured PM2.5 constituents, including black carbon (BC) and ionic species (sulfate - SO42−; nitrate - NO3−; and ammonium - NH4+) at two sites (August 2008 to August 2009) in Karachi. The HA and ERV, respiratory disease outcome data, were collected from three local, large tertiary care hospitals. We assessed the lag structure of excess risk (ER) of the pollutants-outcomes association (0–6 single and cumulative lag days) using time-series quasi-Poisson models after adjusting for temperature, humidity, and day of the week. Among a total 13,827 patients, the highest ERs for all respiratory urgent care use (UCU) were observed for PM2.5 (10.3, 95% CI: 2.59%-18.59), NH4+ (9.58%, 95% CI: 1.50%–18.30%), air quality index (9.11%, 95%CI: 2.54%–16.09%) and SO42− (7.26%, 95% CI: 1.03%–13.87%) within 0–4 lag days. Additionally, patients with chronic obstructive pulmonary disease (COPD), tuberculosis (TB), or other pulmonary diseases and older or male patients were more vulnerable to these pollutants. This first study in Pakistan found that PM2.5 and its constituents were associated with respiratory HAs and ERVs for the inhabitants of the megacity of Karachi. These associations varied by different PM constituents, disease subtypes, age, and gender. Our results provide important information to policymakers for developing regulations for improving air quality and public health. Further studies are urgently needed in other developing countries to disentangle the air pollution health effects.
KW - Air pollution
KW - Morbidity
KW - Pakistan
KW - Particular matter and components
KW - Respiratory diseases
UR - http://www.scopus.com/inward/record.url?scp=85201577352&partnerID=8YFLogxK
U2 - 10.1016/j.apr.2024.102277
DO - 10.1016/j.apr.2024.102277
M3 - Article
AN - SCOPUS:85201577352
SN - 1309-1042
VL - 15
JO - Atmospheric Pollution Research
JF - Atmospheric Pollution Research
IS - 12
M1 - 102277
ER -
