Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study

Daniel B. Blatt, Benjamin Hanisch, Katrina Co, Dibyadyuti Datta, Caitlin Bond, Robert Opoka, Sarah Cusick, Ian Michelow, Chandy John

Research output: Contribution to journalArticle

Abstract

Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality.

Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n=77) or severe malarial anemia (SMA, n=79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n=83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed.

Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P

Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA.

Original languageUndefined/Unknown
JournalPaediatrics and Child Health, East Africa
Publication statusPublished - 1 Aug 2022

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