Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study

Daniel B. Blatt; Benjamin Hanisch; Katrina Co; Dibyadyuti Datta; Caitlin Bond; Robert Opoka; Sarah Cusick; Ian Michelow; Chandy John

Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study

Daniel B. Blatt, Benjamin Hanisch, Katrina Co, Dibyadyuti Datta, Caitlin Bond, Robert Opoka, Sarah Cusick, Ian Michelow, Chandy John

Medical College, East Africa

Research output: Contribution to journal › Article

Abstract

Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality.

Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n=77) or severe malarial anemia (SMA, n=79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n=83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed.

Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P

Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA.

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
Publication status	Published - 1 Aug 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/254

Cite this

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title = "Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study",

abstract = "Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality. Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n=77) or severe malarial anemia (SMA, n=79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n=83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed. Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA.",

author = "Blatt, \{Daniel B.\} and Benjamin Hanisch and Katrina Co and Dibyadyuti Datta and Caitlin Bond and Robert Opoka and Sarah Cusick and Ian Michelow and Chandy John",

year = "2022",

month = aug,

day = "1",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

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TY - JOUR

T1 - Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study

AU - Blatt, Daniel B.

AU - Hanisch, Benjamin

AU - Co, Katrina

AU - Datta, Dibyadyuti

AU - Bond, Caitlin

AU - Opoka, Robert

AU - Cusick, Sarah

AU - Michelow, Ian

AU - John, Chandy

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality. Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n=77) or severe malarial anemia (SMA, n=79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n=83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed. Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA.

AB - Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality. Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n=77) or severe malarial anemia (SMA, n=79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n=83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed. Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA.

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

ER -