Impact of Semaglutide Administration on Weight Loss After Bariatric Surgery: A Meta-Analysis

Tannaz Jamialahamdi; Elaheh Mirhadi; Wael Almahmeed; Salim Virani; Ali H. Eid; Khalid Al-Rasadi; Sepideh Salehabadi; Amirhossein Sahebkar

doi:10.1007/s11695-025-07848-y

Impact of Semaglutide Administration on Weight Loss After Bariatric Surgery: A Meta-Analysis

Tannaz Jamialahamdi, Elaheh Mirhadi, Wael Almahmeed, Salim Virani, Ali H. Eid, Khalid Al-Rasadi, Sepideh Salehabadi, Amirhossein Sahebkar

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Abstract

Background: A significant number of patients encounter weight gain (WG) or inadequate weight loss (IWL) following bariatric surgery for obesity. Recent studies have explored the role of semaglutide in addressing weight management challenges in patients who have inadequate weight loss or weight gain after bariatric surgery. Despite such studies, a systematic review and meta-analysis evaluating the efficacy, safety and tolerability of semaglutide in this specific clinical context remains absent. Therefore, this study was undertaken to address this knowledge gap. Methods: Databases were searched for randomized controlled trials (RCTs), case–control, cohort and observational studies involving use of semaglutide in the intervention arm post-bariatric surgery. Outcome was weight loss post-bariatric surgery. Results: A total of six studies (300 participants) demonstrated significant weight reduction following semaglutide administration after bariatric surgery (WMD: − 15.730, 95% CI: − 22.140, − 9.320, p < 0.001). This effect remained robust in sensitivity analysis. Conclusion: The current data encourages the use of semaglutide for managing WG or IWL post-bariatric surgery.

Original language	English (US)
Pages (from-to)	2490-2497
Number of pages	8
Journal	Obesity Surgery
Volume	35
Issue number	7
DOIs	https://doi.org/10.1007/s11695-025-07848-y
Publication status	Published - Jul 2025

Keywords

GLP agonist
Inadequate weight loss
Meta-analysis
Metabolic surgery
Weight regain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11695-025-07848-y

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title = "Impact of Semaglutide Administration on Weight Loss After Bariatric Surgery: A Meta-Analysis",

abstract = "Background: A significant number of patients encounter weight gain (WG) or inadequate weight loss (IWL) following bariatric surgery for obesity. Recent studies have explored the role of semaglutide in addressing weight management challenges in patients who have inadequate weight loss or weight gain after bariatric surgery. Despite such studies, a systematic review and meta-analysis evaluating the efficacy, safety and tolerability of semaglutide in this specific clinical context remains absent. Therefore, this study was undertaken to address this knowledge gap. Methods: Databases were searched for randomized controlled trials (RCTs), case–control, cohort and observational studies involving use of semaglutide in the intervention arm post-bariatric surgery. Outcome was weight loss post-bariatric surgery. Results: A total of six studies (300 participants) demonstrated significant weight reduction following semaglutide administration after bariatric surgery (WMD: − 15.730, 95\% CI: − 22.140, − 9.320, p < 0.001). This effect remained robust in sensitivity analysis. Conclusion: The current data encourages the use of semaglutide for managing WG or IWL post-bariatric surgery.",

keywords = "GLP agonist, Inadequate weight loss, Meta-analysis, Metabolic surgery, Weight regain",

author = "Tannaz Jamialahamdi and Elaheh Mirhadi and Wael Almahmeed and Salim Virani and Eid, \{Ali H.\} and Khalid Al-Rasadi and Sepideh Salehabadi and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.",

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doi = "10.1007/s11695-025-07848-y",

language = "English (US)",

volume = "35",

pages = "2490--2497",

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T1 - Impact of Semaglutide Administration on Weight Loss After Bariatric Surgery

T2 - A Meta-Analysis

AU - Jamialahamdi, Tannaz

AU - Mirhadi, Elaheh

AU - Almahmeed, Wael

AU - Virani, Salim

AU - Eid, Ali H.

AU - Al-Rasadi, Khalid

AU - Salehabadi, Sepideh

AU - Sahebkar, Amirhossein

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025/7

Y1 - 2025/7

N2 - Background: A significant number of patients encounter weight gain (WG) or inadequate weight loss (IWL) following bariatric surgery for obesity. Recent studies have explored the role of semaglutide in addressing weight management challenges in patients who have inadequate weight loss or weight gain after bariatric surgery. Despite such studies, a systematic review and meta-analysis evaluating the efficacy, safety and tolerability of semaglutide in this specific clinical context remains absent. Therefore, this study was undertaken to address this knowledge gap. Methods: Databases were searched for randomized controlled trials (RCTs), case–control, cohort and observational studies involving use of semaglutide in the intervention arm post-bariatric surgery. Outcome was weight loss post-bariatric surgery. Results: A total of six studies (300 participants) demonstrated significant weight reduction following semaglutide administration after bariatric surgery (WMD: − 15.730, 95% CI: − 22.140, − 9.320, p < 0.001). This effect remained robust in sensitivity analysis. Conclusion: The current data encourages the use of semaglutide for managing WG or IWL post-bariatric surgery.

AB - Background: A significant number of patients encounter weight gain (WG) or inadequate weight loss (IWL) following bariatric surgery for obesity. Recent studies have explored the role of semaglutide in addressing weight management challenges in patients who have inadequate weight loss or weight gain after bariatric surgery. Despite such studies, a systematic review and meta-analysis evaluating the efficacy, safety and tolerability of semaglutide in this specific clinical context remains absent. Therefore, this study was undertaken to address this knowledge gap. Methods: Databases were searched for randomized controlled trials (RCTs), case–control, cohort and observational studies involving use of semaglutide in the intervention arm post-bariatric surgery. Outcome was weight loss post-bariatric surgery. Results: A total of six studies (300 participants) demonstrated significant weight reduction following semaglutide administration after bariatric surgery (WMD: − 15.730, 95% CI: − 22.140, − 9.320, p < 0.001). This effect remained robust in sensitivity analysis. Conclusion: The current data encourages the use of semaglutide for managing WG or IWL post-bariatric surgery.

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KW - Inadequate weight loss

KW - Meta-analysis

KW - Metabolic surgery

KW - Weight regain

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JO - Obesity Surgery

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ER -

Impact of Semaglutide Administration on Weight Loss After Bariatric Surgery: A Meta-Analysis

Abstract

Keywords

UN SDGs

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