Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Engy Shokry; Kamran Sadiq; Sajid Soofi; Atif Habib; Naveed Bhutto; Arjumand Rizvi; Imran Ahmad; Hans Demmelmair; Olaf Uhl; Zulfiqar A. Bhutta; Berthold Koletzko

doi:10.3390/nu12072163

Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Engy Shokry
, Kamran Sadiq
, Sajid Soofi
, Atif Habib
, Naveed Bhutto
, Arjumand Rizvi
, Imran Ahmad
, Hans Demmelmair
, Olaf Uhl
, Zulfiqar A. Bhutta
, Berthold Koletzko

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

(1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

Original language	English (US)
Article number	2163
Pages (from-to)	1-23
Number of pages	23
Journal	Nutrients
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/nu12072163
Publication status	Published - Jul 2020

Keywords

Essential fatty acids (EFA)
Glycerophospholipids
Lysophosphatidylcholines (LysoPC)
Metabolomics
Severe acute malnutrition (SAM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12072163

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@article{a4fa52c10a7a48fca207b5ee1b490012,

title = "Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children",

abstract = "(1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.",

keywords = "Essential fatty acids (EFA), Glycerophospholipids, Lysophosphatidylcholines (LysoPC), Metabolomics, Severe acute malnutrition (SAM)",

author = "Engy Shokry and Kamran Sadiq and Sajid Soofi and Atif Habib and Naveed Bhutto and Arjumand Rizvi and Imran Ahmad and Hans Demmelmair and Olaf Uhl and Bhutta, \{Zulfiqar A.\} and Berthold Koletzko",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jul,

doi = "10.3390/nu12072163",

language = "English (US)",

volume = "12",

pages = "1--23",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

AU - Shokry, Engy

AU - Sadiq, Kamran

AU - Soofi, Sajid

AU - Habib, Atif

AU - Bhutto, Naveed

AU - Rizvi, Arjumand

AU - Ahmad, Imran

AU - Demmelmair, Hans

AU - Uhl, Olaf

AU - Bhutta, Zulfiqar A.

AU - Koletzko, Berthold

PY - 2020/7

Y1 - 2020/7

N2 - (1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

AB - (1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

KW - Essential fatty acids (EFA)

KW - Glycerophospholipids

KW - Lysophosphatidylcholines (LysoPC)

KW - Metabolomics

KW - Severe acute malnutrition (SAM)

UR - https://www.scopus.com/pages/publications/85088260487

U2 - 10.3390/nu12072163

DO - 10.3390/nu12072163

M3 - Article

C2 - 32708260

AN - SCOPUS:85088260487

SN - 2072-6643

VL - 12

SP - 1

EP - 23

JO - Nutrients

JF - Nutrients

IS - 7

M1 - 2163

ER -

Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Abstract

Keywords

UN SDGs

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