Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Engy Shokry; Kamran Sadiq; Sajid Soofi; Atif Habib; Naveed Bhutto; Arjumand Rizvi; Imran Ahmad; Hans Demmelmair; Olaf Uhl; Zulfiqar A. Bhutta; Berthold Koletzko

doi:10.3390/nu12072163

Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Engy Shokry, Kamran Sadiq, Sajid Soofi, Atif Habib, Naveed Bhutto, Arjumand Rizvi, Imran Ahmad, Hans Demmelmair, Olaf Uhl, Zulfiqar A. Bhutta, Berthold Koletzko

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

(1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

Original language	English (US)
Article number	2163
Pages (from-to)	1-23
Number of pages	23
Journal	Nutrients
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/nu12072163
Publication status	Published - Jul 2020

Keywords

Essential fatty acids (EFA)
Glycerophospholipids
Lysophosphatidylcholines (LysoPC)
Metabolomics
Severe acute malnutrition (SAM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12072163

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@article{a4fa52c10a7a48fca207b5ee1b490012,

title = "Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children",

abstract = "(1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.",

keywords = "Essential fatty acids (EFA), Glycerophospholipids, Lysophosphatidylcholines (LysoPC), Metabolomics, Severe acute malnutrition (SAM)",

author = "Engy Shokry and Kamran Sadiq and Sajid Soofi and Atif Habib and Naveed Bhutto and Arjumand Rizvi and Imran Ahmad and Hans Demmelmair and Olaf Uhl and Bhutta, \{Zulfiqar A.\} and Berthold Koletzko",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jul,

doi = "10.3390/nu12072163",

language = "English (US)",

volume = "12",

pages = "1--23",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

AU - Shokry, Engy

AU - Sadiq, Kamran

AU - Soofi, Sajid

AU - Habib, Atif

AU - Bhutto, Naveed

AU - Rizvi, Arjumand

AU - Ahmad, Imran

AU - Demmelmair, Hans

AU - Uhl, Olaf

AU - Bhutta, Zulfiqar A.

AU - Koletzko, Berthold

PY - 2020/7

Y1 - 2020/7

N2 - (1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

AB - (1) Background: Little is known on impacts of ready-to-use therapeutic food (RUTF) treatment on lipid metabolism in children with severe acute malnutrition (SAM). (2) Methods: We analyzed glycerophospholipid fatty acids (FA) and polar lipids in plasma of 41 Pakistani children with SAM before and after 3 months of RUTF treatment using gas chromatography and flow-injection analysis tandem mass spectrometry, respectively. Statistical analysis was performed using univariate, multivariate tests and evaluated for the impact of age, sex, breastfeeding status, hemoglobin, and anthropometry. (3) Results: Essential fatty acid (EFA) depletion at baseline was corrected by RUTF treatment which increased EFA. In addition, long-chain polyunsaturated fatty acids (LC-PUFA) and the ratio of arachidonic acid (AA)/linoleic acid increased reflecting greater EFA conversion to LC-PUFA, whereas Mead acid/AA decreased. Among phospholipids, lysophosphatidylcholines (lyso.PC) were most impacted by treatment; in particular, saturated lyso.PC decreased. Higher child age and breastfeeding were associated with great decrease in total saturated FA (ΣSFA) and lesser decrease in monounsaturated FA and total phosphatidylcholines (ΣPC). Conclusions: RUTF treatment improves EFA deficiency in SAM, appears to enhance EFA conversion to biologically active LC-PUFA, and reduces lipolysis reflected in decreased ΣSFA and saturated lyso.PC. Child age and breastfeeding modify treatment-induced changes in ΣSFA and ΣPC.

KW - Essential fatty acids (EFA)

KW - Glycerophospholipids

KW - Lysophosphatidylcholines (LysoPC)

KW - Metabolomics

KW - Severe acute malnutrition (SAM)

UR - https://www.scopus.com/pages/publications/85088260487

U2 - 10.3390/nu12072163

DO - 10.3390/nu12072163

M3 - Article

C2 - 32708260

AN - SCOPUS:85088260487

SN - 2072-6643

VL - 12

SP - 1

EP - 23

JO - Nutrients

JF - Nutrients

IS - 7

M1 - 2163

ER -

Impact of treatment with rutf on plasma lipid profiles of severely malnourished pakistani children

Abstract

Keywords

UN SDGs

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