Improving diabetes care: Multi-component cardiovascular disease risk reduction strategies for people with diabetes in South Asia-The CARRS Multi-center Translation Trial

Seema Shah, Kavita Singh, Mohammed K. Ali, V. Mohan, Muhammad Masood Kadir, A. G. Unnikrishnan, Rakesh Kumar Sahay, Premlata Varthakavi, Mala Dharmalingam, Vijay Viswanathan, Qamar Masood, Ganapathi Bantwal, Rajesh Khadgawat, Ankush Desai, Bipin Kumar Sethi, Roopa Shivashankar, Vamadevan S. Ajay, K. Srinath Reddy, K. M.Venkat Narayan, Dorairaj PrabhakaranNikhil Tandon

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Aims: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in people with diabetes in South Asia. The CARRS Translation Trial tests the effectiveness, cost-effectiveness, and sustainability of a clinic-based multi-component CVD risk reduction intervention among people with diabetes in India and Pakistan. Methods: We randomly assigned 1146 adults with diabetes recruited from 10 urban clinic sites, to receive usual care by physicians or to receive an integrated multi-component CVD risk reduction intervention. The intervention involves electronic health record management, decision-support prompts to the healthcare team, and the support of a care coordinator to actively facilitate patient and provider adherence to evidence-based guidelines. The primary outcome is a composite of multiple CVD risk factor control (blood glucose and either blood pressure or cholesterol, or all three). Other outcomes include control of the individual CVD risk factors, process and patient-centered measures, cost-effectiveness, and acceptability/feasibility. Conclusion: The CARRS Translation Trial tests a low-cost diabetes care delivery model in urban South Asia to achieve comprehensive cardio-metabolic disease case-management of high-risk patients (clinicaltrials.gov number: NCT01212328).

Original languageEnglish
Pages (from-to)285-294
Number of pages10
JournalDiabetes Research and Clinical Practice
Volume98
Issue number2
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Cardiovascular risk
  • Diabetes
  • Healthcare delivery
  • South Asia
  • Translation research

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