TY - JOUR
T1 - Improving diabetes care
T2 - Multi-component cardiovascular disease risk reduction strategies for people with diabetes in South Asia-The CARRS Multi-center Translation Trial
AU - Shah, Seema
AU - Singh, Kavita
AU - Ali, Mohammed K.
AU - Mohan, V.
AU - Kadir, Muhammad Masood
AU - Unnikrishnan, A. G.
AU - Sahay, Rakesh Kumar
AU - Varthakavi, Premlata
AU - Dharmalingam, Mala
AU - Viswanathan, Vijay
AU - Masood, Qamar
AU - Bantwal, Ganapathi
AU - Khadgawat, Rajesh
AU - Desai, Ankush
AU - Sethi, Bipin Kumar
AU - Shivashankar, Roopa
AU - Ajay, Vamadevan S.
AU - Reddy, K. Srinath
AU - Narayan, K. M.Venkat
AU - Prabhakaran, Dorairaj
AU - Tandon, Nikhil
N1 - Funding Information:
The CARRS Translation Trial has been funded in whole or in part by the National Heart, Lung, and Blood Institute , National Institutes of Health (NIH) , Department of Health and Human Services , under contract number HHSN268200900026C , and the United Health Group, Minneapolis, MN, USA . The NIH support ( $3,225,619 ) accounts for 74% of funding for Center of Excellence – Center for Cardio-metabolic Risk Reduction in South Asia (CoE-CARRS), while the remaining (26%) portion of the support is from the UnitedHealth Group . Several members of the research team at Public Health Foundation of India (PHFI), Emory University, and Centre for Chronic Disease Control (CCDC) were/are supported by the Fogarty International Clinical Research Scholars – Fellows program (FICRS-F) through grant number 5R24TW007988 from NIH, Fogarty International Center (FIC) through Vanderbilt University , Emory's Global Health Institute , and D43 NCDs in India Training Program through award number 1D43HD05249 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) and FIC . However, the contents of this paper are solely the responsibility of the writing group (the authors) and do not necessarily represent the official views of FIC, Vanderbilt University, Emory University, PHFI, NICHD, or the NIH.
PY - 2012/11
Y1 - 2012/11
N2 - Aims: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in people with diabetes in South Asia. The CARRS Translation Trial tests the effectiveness, cost-effectiveness, and sustainability of a clinic-based multi-component CVD risk reduction intervention among people with diabetes in India and Pakistan. Methods: We randomly assigned 1146 adults with diabetes recruited from 10 urban clinic sites, to receive usual care by physicians or to receive an integrated multi-component CVD risk reduction intervention. The intervention involves electronic health record management, decision-support prompts to the healthcare team, and the support of a care coordinator to actively facilitate patient and provider adherence to evidence-based guidelines. The primary outcome is a composite of multiple CVD risk factor control (blood glucose and either blood pressure or cholesterol, or all three). Other outcomes include control of the individual CVD risk factors, process and patient-centered measures, cost-effectiveness, and acceptability/feasibility. Conclusion: The CARRS Translation Trial tests a low-cost diabetes care delivery model in urban South Asia to achieve comprehensive cardio-metabolic disease case-management of high-risk patients (clinicaltrials.gov number: NCT01212328).
AB - Aims: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in people with diabetes in South Asia. The CARRS Translation Trial tests the effectiveness, cost-effectiveness, and sustainability of a clinic-based multi-component CVD risk reduction intervention among people with diabetes in India and Pakistan. Methods: We randomly assigned 1146 adults with diabetes recruited from 10 urban clinic sites, to receive usual care by physicians or to receive an integrated multi-component CVD risk reduction intervention. The intervention involves electronic health record management, decision-support prompts to the healthcare team, and the support of a care coordinator to actively facilitate patient and provider adherence to evidence-based guidelines. The primary outcome is a composite of multiple CVD risk factor control (blood glucose and either blood pressure or cholesterol, or all three). Other outcomes include control of the individual CVD risk factors, process and patient-centered measures, cost-effectiveness, and acceptability/feasibility. Conclusion: The CARRS Translation Trial tests a low-cost diabetes care delivery model in urban South Asia to achieve comprehensive cardio-metabolic disease case-management of high-risk patients (clinicaltrials.gov number: NCT01212328).
KW - Cardiovascular risk
KW - Diabetes
KW - Healthcare delivery
KW - South Asia
KW - Translation research
UR - http://www.scopus.com/inward/record.url?scp=84870556045&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2012.09.023
DO - 10.1016/j.diabres.2012.09.023
M3 - Article
C2 - 23084280
AN - SCOPUS:84870556045
SN - 0168-8227
VL - 98
SP - 285
EP - 294
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 2
ER -
