In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark

Hafiz Allah Bachaya; Zafar Iqbal; Muhammad Nisar Khan; Abdul Jabbar; Anwarul Hassan Gilani; Islam-Ud-Din

In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark

Hafiz Allah Bachaya, Zafar Iqbal, Muhammad Nisar Khan, Abdul Jabbar, Anwarul Hassan Gilani, Islam-Ud-Din

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The present study was carried out to evaluate the anthelmintic activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintic. Lethal median concentration (LC₅₀ values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 μg mL^-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g kg^-1 body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintic activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	International Journal of Agriculture and Biology
Volume	11
Issue number	3
Publication status	Published - 2009
Externally published	Yes

Keywords

Anthelmintic
Bark
Sheep
Terminalia arjuna

Cite this

@article{c68508da07aa487287151854e64d534b,

title = "In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark",

abstract = "The present study was carried out to evaluate the anthelmintic activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintic. Lethal median concentration (LC50 values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 μg mL-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g kg-1 body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintic activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.",

keywords = "Anthelmintic, Bark, Sheep, Terminalia arjuna",

author = "Bachaya, {Hafiz Allah} and Zafar Iqbal and Khan, {Muhammad Nisar} and Abdul Jabbar and Gilani, {Anwarul Hassan} and Islam-Ud-Din",

year = "2009",

language = "English",

volume = "11",

pages = "273--278",

journal = "International Journal of Agriculture and Biology",

issn = "1560-8530",

publisher = "Friends Science Publishers",

number = "3",

}

TY - JOUR

T1 - In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark

AU - Bachaya, Hafiz Allah

AU - Iqbal, Zafar

AU - Khan, Muhammad Nisar

AU - Jabbar, Abdul

AU - Gilani, Anwarul Hassan

AU - Islam-Ud-Din,

PY - 2009

Y1 - 2009

N2 - The present study was carried out to evaluate the anthelmintic activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintic. Lethal median concentration (LC50 values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 μg mL-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g kg-1 body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintic activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.

AB - The present study was carried out to evaluate the anthelmintic activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintic. Lethal median concentration (LC50 values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 μg mL-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g kg-1 body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintic activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.

KW - Anthelmintic

KW - Bark

KW - Sheep

KW - Terminalia arjuna

UR - http://www.scopus.com/inward/record.url?scp=67649213749&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:67649213749

SN - 1560-8530

VL - 11

SP - 273

EP - 278

JO - International Journal of Agriculture and Biology

JF - International Journal of Agriculture and Biology

IS - 3

ER -

In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark

Abstract

Keywords

Other files and links

Fingerprint

Cite this