In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark

Hafiz Allah Bachaya, Zafar Iqbal, Muhammad Nisar Khan, Abdul Jabbar, Anwarul Hassan Gilani, Islam-Ud-Din

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

The present study was carried out to evaluate the anthelmintic activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintic. Lethal median concentration (LC50 values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 μg mL-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g kg-1 body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintic activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalInternational Journal of Agriculture and Biology
Volume11
Issue number3
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Anthelmintic
  • Bark
  • Sheep
  • Terminalia arjuna

Fingerprint

Dive into the research topics of 'In vitro and In vivo Anthelmintic activity of Terminalia arjuna bark'. Together they form a unique fingerprint.

Cite this