TY - JOUR
T1 - In vitro susceptibility of typhoidal Salmonellae against newer antimicrobial agents
T2 - A search for alternate treatment options
AU - Qaiser, Saba
AU - Irfan, Seema
AU - Khan, Erum
AU - Ahsan, Tanwir
AU - Zafar, Afia
PY - 2011/5
Y1 - 2011/5
N2 - Objectives: To determine the minimum inhibitory concentrations (MICs) of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem for Salmonella Typhi (S. Typhi) and Paratyphi. Methods: One hundred and fifty four isolates of Salmonella Typhi and S. Paratyphi A, B and C growing in blood culture were selected. MICs of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem were performed byagar dilution method as recommended by clinical laboratory standard institutes. Results: MIC90 of azithromycin and pefloxacin was 8 μg/ ml, cefipime was 0.06 μg/ ml and imipenem was0.5μg/ml. None of the strains were found to be resistant to ceftriaxone but 3 isolates showed higher MIC value of 2μg/ml.Conclusion: Azithromycin appears a suitable alternate for the treatment of typhoid in the community. Imipenemand cefipime are good options in complicated cases to be treated in hospital settings. Pefloxacin cannot be used as MICs are higher. Presence of isolates with higher MIC of ceftriaxone is serious and stresses upon continuous laboratory surveillance to guide clinicians appropriately.
AB - Objectives: To determine the minimum inhibitory concentrations (MICs) of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem for Salmonella Typhi (S. Typhi) and Paratyphi. Methods: One hundred and fifty four isolates of Salmonella Typhi and S. Paratyphi A, B and C growing in blood culture were selected. MICs of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem were performed byagar dilution method as recommended by clinical laboratory standard institutes. Results: MIC90 of azithromycin and pefloxacin was 8 μg/ ml, cefipime was 0.06 μg/ ml and imipenem was0.5μg/ml. None of the strains were found to be resistant to ceftriaxone but 3 isolates showed higher MIC value of 2μg/ml.Conclusion: Azithromycin appears a suitable alternate for the treatment of typhoid in the community. Imipenemand cefipime are good options in complicated cases to be treated in hospital settings. Pefloxacin cannot be used as MICs are higher. Presence of isolates with higher MIC of ceftriaxone is serious and stresses upon continuous laboratory surveillance to guide clinicians appropriately.
KW - Drug resistance
KW - New options
KW - Typhoidal salmonellae
UR - http://www.scopus.com/inward/record.url?scp=79955635873&partnerID=8YFLogxK
M3 - Article
C2 - 22204180
AN - SCOPUS:79955635873
SN - 0030-9982
VL - 61
SP - 462
EP - 465
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 5
ER -