Objectives: To determine the minimum inhibitory concentrations (MICs) of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem for Salmonella Typhi (S. Typhi) and Paratyphi. Methods: One hundred and fifty four isolates of Salmonella Typhi and S. Paratyphi A, B and C growing in blood culture were selected. MICs of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem were performed byagar dilution method as recommended by clinical laboratory standard institutes. Results: MIC90 of azithromycin and pefloxacin was 8 μg/ ml, cefipime was 0.06 μg/ ml and imipenem was0.5μg/ml. None of the strains were found to be resistant to ceftriaxone but 3 isolates showed higher MIC value of 2μg/ml.Conclusion: Azithromycin appears a suitable alternate for the treatment of typhoid in the community. Imipenemand cefipime are good options in complicated cases to be treated in hospital settings. Pefloxacin cannot be used as MICs are higher. Presence of isolates with higher MIC of ceftriaxone is serious and stresses upon continuous laboratory surveillance to guide clinicians appropriately.
|Number of pages||4|
|Journal||JPMA. The Journal of the Pakistan Medical Association|
|Publication status||Published - May 2011|
- Drug resistance
- New options
- Typhoidal salmonellae