Incidence of epilepsy: A systematic review and meta-analysis

A. K. Ngugi; S. M. Kariuki; C. Bottomley; I. Kleinschmidt; J. W. Sander; C. R. Newton

doi:10.1212/WNL.0b013e31822cfc90

Incidence of epilepsy: A systematic review and meta-analysis

A. K. Ngugi, S. M. Kariuki, C. Bottomley, I. Kleinschmidt, J. W. Sander, C. R. Newton

Research output: Contribution to journal › Review article › peer-review

382 Citations (Scopus)

Abstract

Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.

Original language	English (UK)
Pages (from-to)	1005-1012
Number of pages	8
Journal	Neurology
Volume	77
Issue number	10
DOIs	https://doi.org/10.1212/WNL.0b013e31822cfc90
Publication status	Published - 6 Sept 2011
Externally published	Yes

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title = "Incidence of epilepsy: A systematic review and meta-analysis",

abstract = "Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.",

author = "Ngugi, \{A. K.\} and Kariuki, \{S. M.\} and C. Bottomley and I. Kleinschmidt and Sander, \{J. W.\} and Newton, \{C. R.\}",

note = "Funding Information: Study funding: Supported by the Kenya Medical Research Institute (KEMRI) and the Wellcome Trust (United Kingdom) under a grant awarded to C.R.N. (No. 083744). A.K.N. is supported by a Wellcome Trust Strategic Training Award (No. 084538). J.W.S. is based at University College London Hospital/University College London's Comprehensive Biomedical Research Centre, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme. The sponsors played no role in the study design, data collection, analysis, interpretation of data, writing of the article, or the decision to submit for publication. ",

year = "2011",

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doi = "10.1212/WNL.0b013e31822cfc90",

language = "English (UK)",

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TY - JOUR

T1 - Incidence of epilepsy

T2 - A systematic review and meta-analysis

AU - Ngugi, A. K.

AU - Kariuki, S. M.

AU - Bottomley, C.

AU - Kleinschmidt, I.

AU - Sander, J. W.

AU - Newton, C. R.

N1 - Funding Information: Study funding: Supported by the Kenya Medical Research Institute (KEMRI) and the Wellcome Trust (United Kingdom) under a grant awarded to C.R.N. (No. 083744). A.K.N. is supported by a Wellcome Trust Strategic Training Award (No. 084538). J.W.S. is based at University College London Hospital/University College London's Comprehensive Biomedical Research Centre, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme. The sponsors played no role in the study design, data collection, analysis, interpretation of data, writing of the article, or the decision to submit for publication.

PY - 2011/9/6

Y1 - 2011/9/6

N2 - Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.

AB - Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.

UR - https://www.scopus.com/pages/publications/80055085208

U2 - 10.1212/WNL.0b013e31822cfc90

DO - 10.1212/WNL.0b013e31822cfc90

M3 - Review article

C2 - 21893672

AN - SCOPUS:80055085208

SN - 0028-3878

VL - 77

SP - 1005

EP - 1012

JO - Neurology

JF - Neurology

IS - 10

ER -

Incidence of epilepsy: A systematic review and meta-analysis

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