TY - JOUR
T1 - Increased body fat percentage and physical inactivity are independent predictors of gestational diabetes mellitus in South Asian women
AU - Iqbal, R.
AU - Rafique, G.
AU - Badruddin, S.
AU - Qureshi, R.
AU - Cue, R.
AU - Gray-Donald, K.
N1 - Funding Information:
Research grant for this study was received from the Aga Khan University’s Research Council, Pakistan. RI is the recipient of the Canadian Commonwealth Scholarship during her doctoral studies at McGill, Canada. The contributors thank Dr Arriaza at the Centers for Disease Control and Prevention (CDC) for providing the MOSPA algorithm for analysis of our physical activity data. We also thank Dr Fareeha Warsi for data collection and Louise Johnson-Down for help in dietary analysis.
PY - 2007/6
Y1 - 2007/6
N2 - Objective: This study aims to identify lifestyle predictors of gestational diabetes mellitus (GDM) in South Asian women. Pre-gravid body mass index, body composition, rate of weight gain during pregnancy, physical activity (PA) and dietary intake were studied. Design: Prospective cohort study (n = 611) of South Asian women at Aga Khan University Hospital antenatal clinic in Karachi, Pakistan. Weight, height and body fat % were measured and data on PA, diet and socio-economic covariates were collected at baseline. A glucose screen was performed at 29.8±2.6 weeks. Results: Using logistic regression analysis for the full cohort, the risk of GDM increased with older maternal age (odds ratio (OR) 1.13, confidence interval (CI) 1.06-1.21), increased body fat % (OR 1.07, CI 1.03-1.13) and the risk was inversely associated with PA (100 kcal) (OR 0.79 0.99, CI 0.89). Using a nested case (n = 49) control (n = 98) design to study dietary intake, the risk of GDM decreased with increasing protein (% energy) in the diet (OR 0.75, CI 0.60-0.95). Conclusions: Body fat %, physical inactivity and, possibly, diet quality are important modifiable risk factors for GDM.
AB - Objective: This study aims to identify lifestyle predictors of gestational diabetes mellitus (GDM) in South Asian women. Pre-gravid body mass index, body composition, rate of weight gain during pregnancy, physical activity (PA) and dietary intake were studied. Design: Prospective cohort study (n = 611) of South Asian women at Aga Khan University Hospital antenatal clinic in Karachi, Pakistan. Weight, height and body fat % were measured and data on PA, diet and socio-economic covariates were collected at baseline. A glucose screen was performed at 29.8±2.6 weeks. Results: Using logistic regression analysis for the full cohort, the risk of GDM increased with older maternal age (odds ratio (OR) 1.13, confidence interval (CI) 1.06-1.21), increased body fat % (OR 1.07, CI 1.03-1.13) and the risk was inversely associated with PA (100 kcal) (OR 0.79 0.99, CI 0.89). Using a nested case (n = 49) control (n = 98) design to study dietary intake, the risk of GDM decreased with increasing protein (% energy) in the diet (OR 0.75, CI 0.60-0.95). Conclusions: Body fat %, physical inactivity and, possibly, diet quality are important modifiable risk factors for GDM.
UR - http://www.scopus.com/inward/record.url?scp=34447104559&partnerID=8YFLogxK
U2 - 10.1038/sj.ejcn.1602574
DO - 10.1038/sj.ejcn.1602574
M3 - Article
C2 - 17180158
AN - SCOPUS:34447104559
SN - 0954-3007
VL - 61
SP - 736
EP - 742
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 6
ER -
