Infant body composition at 6 and 24 months: what are the driving factors?

Ina S. Santos; Caroline S. Costa; Andrew P. Hills; Shabina Ariff; V. Pujitha Wickramasinghe; Shane Norris; Alexia J. Murphy-Alford; Christine Slater; Nishani Lucas; Lukhanyo H. Nyati; Anura V. Kurpad; Kiran D.K. Ahuja; Rebecca Kuriyan; Lukhanyo Nyati; Tanvir Ahmad; Jeffrey M. Beckett; Renata M. Bielemann; Nuala M. Byrne; Laila Charania; Michele P. Christian; Priscilla J. Divya; Anne Hanley; Manoja P. Herath; Leila C. Ismail; Sisitha Jayasinghe; Pulani Lanerolle; Cornelia Loechl; Najat Moktar; Upul Senerath; Sajid Soofi; Steven J. Street; Neiva C.J. Valle; Ayesha Yameen

doi:10.1038/s41430-023-01321-8

Infant body composition at 6 and 24 months: what are the driving factors?

Ina S. Santos, Caroline S. Costa, Andrew P. Hills, Shabina Ariff, V. Pujitha Wickramasinghe, Shane Norris, Alexia J. Murphy-Alford, Christine Slater, Nishani Lucas, Lukhanyo H. Nyati, Anura V. Kurpad, Kiran D.K. Ahuja, Rebecca Kuriyan, Lukhanyo Nyati, Tanvir Ahmad, Jeffrey M. Beckett, Renata M. Bielemann, Nuala M. Byrne, Laila Charania, Michele P. ChristianPriscilla J. Divya, Anne Hanley, Manoja P. Herath, Leila C. Ismail, Sisitha Jayasinghe, Pulani Lanerolle, Cornelia Loechl, Najat Moktar, Upul Senerath, Sajid Soofi, Steven J. Street, Neiva C.J. Valle, Ayesha Yameen

Department of Paediatrics and Child Health, Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background/Objective: Available evidence on infant body composition is limited. This study aimed to investigate factors associated with body composition at 6 and 24 months. Subjects/Methods: Multicenter study with data from a 0 to 6-mo cohort (Australia, India and South Africa) and a 3 to 24-mo cohort (Brazil, Pakistan, South Africa, and Sri Lanka). For the 0–6-mo cohort, body composition was assessed by air-displacement plethysmography (ADP) and for the 3–24-month cohort by the deuterium dilution (DD) technique. Fat mass (FM), fat-free mass (FFM), FM index (FMI), and FFM index (FFMI) were calculated. Independent variables comprised the Gini index of the country, maternal and infant characteristics, and breastfeeding pattern at 3 months. For the 3–24-mo cohort, breastfeeding, and minimum dietary diversity (MDD) at 12 months were also included. Crude and adjusted analyses stratified by sex were conducted by multilevel modelling using mixed models. Results: At 6 months, every 1 kg increase in birth weight was associated with an increase of 0.716 kg in FFM and 0.582 kg/m² in FFMI in girls, whereas in boys, the increase was of 0.277 kg in FFM. At 24 months, compared to those weaned before 12 months, girls still breastfed at 12 months presented a decrease of 0.225 kg in FM, 0.645 kg in FFM and 0.459 kg/m² in FFMI, and in boys the decreases were of 0.467 kg in FM, 0.603 kg in FFM and 0.628 kg/m² in FFMI. Conclusion: Birth weight and breastfeeding are independent predictors of body composition in early life, irrespective of sex.

Original language	English
Journal	European Journal of Clinical Nutrition
DOIs	https://doi.org/10.1038/s41430-023-01321-8
Publication status	Accepted/In press - 2023

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10.1038/s41430-023-01321-8

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Santos, I. S., Costa, C. S., Hills, A. P., Ariff, S., Wickramasinghe, V. P., Norris, S., Murphy-Alford, A. J., Slater, C., Lucas, N., Nyati, L. H., Kurpad, A. V., Ahuja, K. D. K., Kuriyan, R., Nyati, L., Ahmad, T., Beckett, J. M., Bielemann, R. M., Byrne, N. M., Charania, L., ... Yameen, A. (Accepted/In press). Infant body composition at 6 and 24 months: what are the driving factors? European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-023-01321-8

@article{ea112ed58a504a869f097f2053ac131e,

title = "Infant body composition at 6 and 24 months: what are the driving factors?",

abstract = "Background/Objective: Available evidence on infant body composition is limited. This study aimed to investigate factors associated with body composition at 6 and 24 months. Subjects/Methods: Multicenter study with data from a 0 to 6-mo cohort (Australia, India and South Africa) and a 3 to 24-mo cohort (Brazil, Pakistan, South Africa, and Sri Lanka). For the 0–6-mo cohort, body composition was assessed by air-displacement plethysmography (ADP) and for the 3–24-month cohort by the deuterium dilution (DD) technique. Fat mass (FM), fat-free mass (FFM), FM index (FMI), and FFM index (FFMI) were calculated. Independent variables comprised the Gini index of the country, maternal and infant characteristics, and breastfeeding pattern at 3 months. For the 3–24-mo cohort, breastfeeding, and minimum dietary diversity (MDD) at 12 months were also included. Crude and adjusted analyses stratified by sex were conducted by multilevel modelling using mixed models. Results: At 6 months, every 1 kg increase in birth weight was associated with an increase of 0.716 kg in FFM and 0.582 kg/m2 in FFMI in girls, whereas in boys, the increase was of 0.277 kg in FFM. At 24 months, compared to those weaned before 12 months, girls still breastfed at 12 months presented a decrease of 0.225 kg in FM, 0.645 kg in FFM and 0.459 kg/m2 in FFMI, and in boys the decreases were of 0.467 kg in FM, 0.603 kg in FFM and 0.628 kg/m2 in FFMI. Conclusion: Birth weight and breastfeeding are independent predictors of body composition in early life, irrespective of sex.",

author = "Santos, {Ina S.} and Costa, {Caroline S.} and Hills, {Andrew P.} and Shabina Ariff and Wickramasinghe, {V. Pujitha} and Shane Norris and Murphy-Alford, {Alexia J.} and Christine Slater and Nishani Lucas and Nyati, {Lukhanyo H.} and Kurpad, {Anura V.} and Ahuja, {Kiran D.K.} and Rebecca Kuriyan and Lukhanyo Nyati and Tanvir Ahmad and Beckett, {Jeffrey M.} and Bielemann, {Renata M.} and Byrne, {Nuala M.} and Laila Charania and Christian, {Michele P.} and Divya, {Priscilla J.} and Anne Hanley and Herath, {Manoja P.} and Ismail, {Leila C.} and Sisitha Jayasinghe and Pulani Lanerolle and Cornelia Loechl and Najat Moktar and Upul Senerath and Sajid Soofi and Street, {Steven J.} and Valle, {Neiva C.J.} and Ayesha Yameen",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

doi = "10.1038/s41430-023-01321-8",

language = "English",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

}

Santos, IS, Costa, CS, Hills, AP, Ariff, S, Wickramasinghe, VP, Norris, S, Murphy-Alford, AJ, Slater, C, Lucas, N, Nyati, LH, Kurpad, AV, Ahuja, KDK, Kuriyan, R, Nyati, L, Ahmad, T, Beckett, JM, Bielemann, RM, Byrne, NM, Charania, L, Christian, MP, Divya, PJ, Hanley, A, Herath, MP, Ismail, LC, Jayasinghe, S, Lanerolle, P, Loechl, C, Moktar, N, Senerath, U, Soofi, S, Street, SJ, Valle, NCJ & Yameen, A 2023, 'Infant body composition at 6 and 24 months: what are the driving factors?', European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-023-01321-8

TY - JOUR

T1 - Infant body composition at 6 and 24 months

T2 - what are the driving factors?

AU - Santos, Ina S.

AU - Costa, Caroline S.

AU - Hills, Andrew P.

AU - Ariff, Shabina

AU - Wickramasinghe, V. Pujitha

AU - Norris, Shane

AU - Murphy-Alford, Alexia J.

AU - Slater, Christine

AU - Lucas, Nishani

AU - Nyati, Lukhanyo H.

AU - Kurpad, Anura V.

AU - Ahuja, Kiran D.K.

AU - Kuriyan, Rebecca

AU - Nyati, Lukhanyo

AU - Ahmad, Tanvir

AU - Beckett, Jeffrey M.

AU - Bielemann, Renata M.

AU - Byrne, Nuala M.

AU - Charania, Laila

AU - Christian, Michele P.

AU - Divya, Priscilla J.

AU - Hanley, Anne

AU - Herath, Manoja P.

AU - Ismail, Leila C.

AU - Jayasinghe, Sisitha

AU - Lanerolle, Pulani

AU - Loechl, Cornelia

AU - Moktar, Najat

AU - Senerath, Upul

AU - Soofi, Sajid

AU - Street, Steven J.

AU - Valle, Neiva C.J.

AU - Yameen, Ayesha

PY - 2023

Y1 - 2023

N2 - Background/Objective: Available evidence on infant body composition is limited. This study aimed to investigate factors associated with body composition at 6 and 24 months. Subjects/Methods: Multicenter study with data from a 0 to 6-mo cohort (Australia, India and South Africa) and a 3 to 24-mo cohort (Brazil, Pakistan, South Africa, and Sri Lanka). For the 0–6-mo cohort, body composition was assessed by air-displacement plethysmography (ADP) and for the 3–24-month cohort by the deuterium dilution (DD) technique. Fat mass (FM), fat-free mass (FFM), FM index (FMI), and FFM index (FFMI) were calculated. Independent variables comprised the Gini index of the country, maternal and infant characteristics, and breastfeeding pattern at 3 months. For the 3–24-mo cohort, breastfeeding, and minimum dietary diversity (MDD) at 12 months were also included. Crude and adjusted analyses stratified by sex were conducted by multilevel modelling using mixed models. Results: At 6 months, every 1 kg increase in birth weight was associated with an increase of 0.716 kg in FFM and 0.582 kg/m2 in FFMI in girls, whereas in boys, the increase was of 0.277 kg in FFM. At 24 months, compared to those weaned before 12 months, girls still breastfed at 12 months presented a decrease of 0.225 kg in FM, 0.645 kg in FFM and 0.459 kg/m2 in FFMI, and in boys the decreases were of 0.467 kg in FM, 0.603 kg in FFM and 0.628 kg/m2 in FFMI. Conclusion: Birth weight and breastfeeding are independent predictors of body composition in early life, irrespective of sex.

AB - Background/Objective: Available evidence on infant body composition is limited. This study aimed to investigate factors associated with body composition at 6 and 24 months. Subjects/Methods: Multicenter study with data from a 0 to 6-mo cohort (Australia, India and South Africa) and a 3 to 24-mo cohort (Brazil, Pakistan, South Africa, and Sri Lanka). For the 0–6-mo cohort, body composition was assessed by air-displacement plethysmography (ADP) and for the 3–24-month cohort by the deuterium dilution (DD) technique. Fat mass (FM), fat-free mass (FFM), FM index (FMI), and FFM index (FFMI) were calculated. Independent variables comprised the Gini index of the country, maternal and infant characteristics, and breastfeeding pattern at 3 months. For the 3–24-mo cohort, breastfeeding, and minimum dietary diversity (MDD) at 12 months were also included. Crude and adjusted analyses stratified by sex were conducted by multilevel modelling using mixed models. Results: At 6 months, every 1 kg increase in birth weight was associated with an increase of 0.716 kg in FFM and 0.582 kg/m2 in FFMI in girls, whereas in boys, the increase was of 0.277 kg in FFM. At 24 months, compared to those weaned before 12 months, girls still breastfed at 12 months presented a decrease of 0.225 kg in FM, 0.645 kg in FFM and 0.459 kg/m2 in FFMI, and in boys the decreases were of 0.467 kg in FM, 0.603 kg in FFM and 0.628 kg/m2 in FFMI. Conclusion: Birth weight and breastfeeding are independent predictors of body composition in early life, irrespective of sex.

UR - http://www.scopus.com/inward/record.url?scp=85167517231&partnerID=8YFLogxK

U2 - 10.1038/s41430-023-01321-8

DO - 10.1038/s41430-023-01321-8

M3 - Article

AN - SCOPUS:85167517231

SN - 0954-3007

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

ER -

Infant body composition at 6 and 24 months: what are the driving factors?

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