Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)

Z. Merali; S. Kacew; R. B. Koch; R. L. Singhal

doi:10.1016/0306-3623(75)90028-2

Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)

Z. Merali, S. Kacew, R. B. Koch, R. L. Singhal

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10^-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.

Original language	English
Pages (from-to)	299-301
Number of pages	3
Journal	Vascular Pharmacology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(75)90028-2
Publication status	Published - Dec 1975
Externally published	Yes

Keywords

Plictran
acaricide
adenylate cyclase
rat liver
tricyclohexylhydroxytin

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10.1016/0306-3623(75)90028-2

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title = "Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)",

abstract = "1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.",

keywords = "Plictran, acaricide, adenylate cyclase, rat liver, tricyclohexylhydroxytin",

author = "Z. Merali and S. Kacew and Koch, {R. B.} and Singhal, {R. L.}",

year = "1975",

month = dec,

doi = "10.1016/0306-3623(75)90028-2",

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T1 - Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)

AU - Merali, Z.

AU - Kacew, S.

AU - Koch, R. B.

AU - Singhal, R. L.

PY - 1975/12

Y1 - 1975/12

N2 - 1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.

AB - 1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.

KW - Plictran

KW - acaricide

KW - adenylate cyclase

KW - rat liver

KW - tricyclohexylhydroxytin

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DO - 10.1016/0306-3623(75)90028-2

M3 - Article

AN - SCOPUS:49549145082

SN - 0306-3623

VL - 6

SP - 299

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JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 4

ER -

Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)

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