Inhibition of rat liver adenylate cyclase by tricyclohexylhydroxytin (Plictran)

Z. Merali, S. Kacew, R. B. Koch, R. L. Singhal

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalVascular Pharmacology
Issue number4
Publication statusPublished - Dec 1975
Externally publishedYes


  • Plictran
  • acaricide
  • adenylate cyclase
  • rat liver
  • tricyclohexylhydroxytin


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