1. 1. Rat hepatic adenylate cyclase was found to be sensitive to the in vitro action of tricyclohexylhydroxytin (Plictran), an acaricide. 2. 2. Incubation of hepatic tissue homogenates with plictran resulted in marked inhibition of adenylate cyclase activity with 50% inhibition of the enzyme seen at 1 × 10-6 M concentration. 3. 3. Basal form of adenylate cyclase was more sensitive to plictran than the fluoride-stimulated enzyme. 4. 4. Inhibition of adenylate cyclase by this acaricide was time-dependent with significant decrease being detected as early as 10 min following in vitro exposure to plictran.
- adenylate cyclase
- rat liver