Insight into mechanism underlying the medicinal use of Cydonia oblonga in gut and airways disorders

K. H. Janbaz, A. Shabbir, M. H. Mehmood, A. H. Gilani

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

This study was intended to provide the pharmacological rationalization for the medicinal use of Cydonia oblonga in gut and airways diseases. Results showed that the crude extract of Cydonia oblonga seeds (Co.Cr) produced atropinesensitive spasmodic effects in isolated ileum of guinea-pig and rabbit jejunum preparations. In rabbit jejunum, Co.Cr also showed relaxant activity at slightly higher concentrations (0.1-10 mg/mL). When analyzed on rabbit jejunum precontracted with K+ (80 mM), the plant extract (0.003-10 mg/mL) produced relaxation. A rightward shifting of Ca++ dose-response curves along with decline in the maximum response was observed after pretreatment with Co.Cr (0.0030.01 mg/mL), which was similar to the effect of verapamil. The plant extract (0.01-10 mg/mL) relaxed CCh (1 μM) and K+ (80 mM)-induced contractions of isolated rabbit tracheal preparations, similar to the effect produced by verapamil. Data show that Cydonia oblonga possesses spasmogenic effect mediated through cholinergic pathway, while Ca++ antagonist like mechanism is found responsible for its spasmolytic activity, thus provides justification for the medicinal use of the plant in gut and airways disorders.

Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalJournal of Animal and Plant Sciences
Volume23
Issue number1
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Antispasmodic
  • Ca antagonist
  • Cholinergic
  • Cydonia oblong
  • Gut
  • Spasmodic
  • Trachea

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