Insights into embryology and development of omphalocele

Faraz A. Khan, Asra Hashmi, Saleem Islam

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Congenital abdominal wall defects are one of the most common human birth defects with an incidence of about 1 in 2000 live births. While often discussed together abdominal wall defects consist mainly of two distinct entities namely gastroschisis and omphalocele. There is no clear consensus explaining the precise embryological mechanisms leading to the development of an omphalocele. Many clinicians and embryologists have attempted to explain congenital malformation as a result of failure of progression of normal embryonic development. This review summarizes the mechanisms involved in normal and abnormal development of the ventral abdominal wall.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalSeminars in Pediatric Surgery
Issue number2
Publication statusPublished - Apr 2019
Externally publishedYes


  • Abdominal wall development
  • Congenital abdominal wall defect
  • Omphalocele


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