TY - JOUR
T1 - Integrative Genetic Approach Facilitates Precision Strategies for Acute Myocardial Infarction
AU - Khawaja, Muzamil
AU - Siddiqui, Rehma
AU - Virani, Salim S.
AU - Amos, Christopher I.
AU - Bandyopadhyay, Dhrubajyoti
AU - Virk, Hafeez Ul Hassan
AU - Alam, Mahboob
AU - Jneid, Hani
AU - Krittanawong, Chayakrit
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/7
Y1 - 2023/7
N2 - Acute myocardial infarction remains a significant cause of mortality worldwide and its burden continues to grow. Its pathophysiology is known to be complex and multifactorial, with several acquired and inherited risk factors. As advances in technology and medical therapy continue, there is now increasing recognition of the role that genetics play in the development and management of myocardial infarction. The genetic determinants of acute coronary syndrome are still vastly understudied, but the advent of whole-genome scanning and genome-wide association studies has significantly expanded the current understanding of genetics and simultaneously fostered hope that genetic profiling and gene-guided treatments could substantially impact clinical outcomes. The identification of genes associated with acute myocardial infarction can help in the development of personalized medicine, risk stratification, and improved therapeutic strategies. In this context, several genes have been studied, and their potential involvement in increasing the risk for acute myocardial infarction is being investigated. As such, this article provides a review of some of the genes potentially related to an increased risk for acute myocardial infarction as well as the latest updates in gene-guided risk stratification and treatment strategies.
AB - Acute myocardial infarction remains a significant cause of mortality worldwide and its burden continues to grow. Its pathophysiology is known to be complex and multifactorial, with several acquired and inherited risk factors. As advances in technology and medical therapy continue, there is now increasing recognition of the role that genetics play in the development and management of myocardial infarction. The genetic determinants of acute coronary syndrome are still vastly understudied, but the advent of whole-genome scanning and genome-wide association studies has significantly expanded the current understanding of genetics and simultaneously fostered hope that genetic profiling and gene-guided treatments could substantially impact clinical outcomes. The identification of genes associated with acute myocardial infarction can help in the development of personalized medicine, risk stratification, and improved therapeutic strategies. In this context, several genes have been studied, and their potential involvement in increasing the risk for acute myocardial infarction is being investigated. As such, this article provides a review of some of the genes potentially related to an increased risk for acute myocardial infarction as well as the latest updates in gene-guided risk stratification and treatment strategies.
KW - acute myocardial infarction
KW - genetics
KW - precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85165938408&partnerID=8YFLogxK
U2 - 10.3390/genes14071340
DO - 10.3390/genes14071340
M3 - Review article
C2 - 37510245
AN - SCOPUS:85165938408
SN - 2073-4425
VL - 14
JO - Genes
JF - Genes
IS - 7
M1 - 1340
ER -