Intensive care outcomes and mortality prediction at a National Referral Hospital in Western Kenya

Hussain S. Lalani, Wangari Waweru-Siika, Thomas Mwogi, Protus Kituyi, Joseph R. Egger, Lawrence P. Park, Peter S. Kussin

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Rationale: The burden of critical care is greatest in resourcelimited settings. Intensive care unit (ICU) outcomes at public hospitals in Kenya are unknown. The present study is timely, given the Kenyan Ministry of Health initiative to expand ICU capacity. Objectives: To identify factors associated with mortality at Moi Teaching and Referral Hospital and validate the Mortality Probability Admission Model II (MPM0-II). Methods: A retrospective cohort of 450 patients from January 1, 2013, to April 5, 2015, was evaluated using demographics, presenting diagnoses, interventions, mortality, and cost data. Results: ICU mortality was 53.6%, and 30-day mortality was 57.3%. Most patients were male (61%) and at least 18 years old (70%); the median age was 29 years. Factors associated with high adjusted odds of mortality were as follows: Age younger than 10 years (adjusted odds ratio [aOR], 3.59; P<0.001), ages 35-49 years (aOR, 3.13; P = 0.002), and age above 50 years (aOR, 2.86; P = 0.004), with reference age range 10-24 years; sepsis (aOR, 3.39; P = 0.01); acute stroke (aOR, 8.14; P = 0.011); acute respiratory failure or mechanical ventilation (aOR, 6.37; P,0.001); and vasopressor support (aOR, 7.98; P,0.001). Drug/alcohol poisoning (aOR, 0.33; P = 0.005) was associated with lower adjusted odds of mortality. MPM0-II discrimination showed an area under the receiver operating characteristic curve of 0.78 (95% confidence interval, 0.72-0.82). The result of the Hosmer-Lemeshow test for calibration was significant (P,0.001). Conclusions: In a Kenyan public ICU, high mortality was noted despite the use of advanced therapies. MPM0-II has acceptable discrimination but poor calibration. Modification of MPM0-II or development of a new model using a prospective multicenter global collaboration is needed. Standardized triage and treatment protocols for high-risk diagnoses are needed to improve ICU outcomes.

Original languageEnglish
Pages (from-to)1336-1343
Number of pages8
JournalAnnals of the American Thoracic Society
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Critical care
  • Critical care outcomes
  • Forecasting
  • Kenya

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