Abstract
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 396-407 |
| Number of pages | 12 |
| Journal | American Journal of Infection Control |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Jun 2012 |
Keywords
- Antibiotic resistance
- Bloodstream infection
- Catheter-associated urinary tract infection
- Central line-associated bloodstream infection
- Developing countries
- Device-associated infection
- Health care-associated infection
- Hospital infection
- Limited-resources countries
- Low-income countries
- Network
- Nosocomial infection
- Urinary tract infection
- Ventilator-associated pneumonia
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In: American Journal of Infection Control, Vol. 40, No. 5, 01.06.2012, p. 396-407.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009
AU - Rosenthal, Victor D.
AU - Bijie, Hu
AU - Maki, Dennis G.
AU - Mehta, Yatin
AU - Apisarnthanarak, Anucha
AU - Medeiros, Eduardo A.
AU - Leblebicioglu, Hakan
AU - Fisher, Dale
AU - Álvarez-Moreno, Carlos
AU - Khader, Ilham Abu
AU - Martínez, Marisela Del Rocío González
AU - Cuellar, Luis E.
AU - Navoa-Ng, Josephine Anne
AU - Abouqal, Rédouane
AU - Garcell, Humberto Guanche
AU - Mitrev, Zan
AU - García, María Catalina Pirez
AU - Hamdi, Asma
AU - Dueñas, Lourdes
AU - Cancel, Elsie
AU - Gurskis, Vaidotas
AU - Rasslan, Ossama
AU - Ahmed, Altaf
AU - Kanj, Souha S.
AU - Ugalde, Olber Chavarría
AU - Mapp, Trudell
AU - Raka, Lul
AU - Meng, Cheong Yuet
AU - Thu, Le Thi Anh
AU - Ghazal, Sameeh
AU - Gikas, Achilleas
AU - Narváez, Leonardo Pazmiño
AU - Mejía, Nepomuceno
AU - Hadjieva, Nassya
AU - Elanbya, May Osman Gamar
AU - Siritt, María Eugenia Guzmán
AU - Jayatilleke, Kushlani
AU - Frías, María Laura
AU - Churruarín, Griselda
AU - Sztokhamer, Daniel
AU - Flynn, Luis Pedro
AU - Rausch, Diego
AU - Spagnolo, Alejandro
AU - Santero, Beatriz
AU - Soroka, Luisa C.
AU - For-Ciniti, Silvia
AU - Blasco, Marta
AU - Lezcano, Carmen B.
AU - Lastra, Carlos Esteban
AU - Bedoya, Miguel Ángel Fernández
AU - Costamagna, Adrián
AU - Dheza, Gustavo Ruiz
AU - Ávalos, Jorge
AU - Álvarez, Marcelo
AU - Bench-Etrit, Guillermo
AU - Bonaventura, Claudio
AU - Caridi, Maria de los Ángeles
AU - Messina, Adriana
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AU - Lan-Zetta, Diana
AU - Fernández, Leonardo J.
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AU - Migazzi, Claudia
AU - Barolin, Clarisa
AU - Martínez, Estela
AU - Bernan, Marisa Liliana
AU - Bay, María Rosa
AU - Diaz, Flavia Ruiz
AU - Dominguez, Claudia Beatriz
AU - Coria, Gloria Ester
AU - Martinelli, María Elena
AU - Grinberg, Gorki
AU - Ferreira, Iselde Buchner
AU - Cechinel, Raquel Bauer
AU - Zanandrea, Bruna Boaria
AU - Rohnkohl, Carolina
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AU - Spessatto, Jamile Leda
AU - Pasini, Ricardo Scopel
AU - Ferla, Shaline
AU - Salomao, Reinaldo
AU - da Silva, Maria Ângela Maretti
AU - de Jesus Silva, Clélia Heloísa
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AU - Blecher, Sergio
AU - Angelieri, Daniela Bicudo
AU - Kuchenbecker, Ricardo de Souza
AU - Pires, Márcia Rosane
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AU - Santos, Rodrigo Pires Dos
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AU - Biancalana, María Lucia Neves
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AU - Abreu, Juliana Silva De
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AU - Rodríguez, Tatiana
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AU - Ziqin, Xu
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AU - Chun, Gao Sheng
AU - Yang, Xuesong
AU - Gan, Aiguo
AU - Zhang, Aiguo
AU - Luo, Jiangmeng
AU - Zhao, Aihua
AU - Li, Fenghong
AU - Liu, Baozheng
AU - Gao, Meiying
AU - Zhao, Bo
AU - Wei, Ling
AU - Wang, Chuanqing
AU - Fang, Lanzhi
AU - Yi, Chuntao
AU - Xie, Xiaoling
AU - Ling, Fang
AU - Wu, Yuxin
AU - Xu, Fangrui
AU - Feng, Fang
AU - Weng, Fangyi
AU - Dong, Gui Hong
AU - Ye, Guxiang
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AU - Yang, Huiy Ing
AU - Yan, Huafang
AU - Mao, Aihua
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AU - Tang, Dongping
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AU - Qiu, Youdi
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AU - Miu, Jin
AU - Zhao, Wenqi
AU - Shi, Junfeng
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AU - Duo, Kewei
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AU - Liu, Lei
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AU - Lu, Qing
AU - Li, Guanghui
AU - Sun, Ruizheng
AU - Yu, Haichun
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AU - Wang, Weixiu
AU - Shen, Yimian
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AU - Chen, Haiwei
AU - Yao, Xiaoping
AU - Wen, Hui
AU - Xiong, Xudong
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AU - Huang, Mingmin
AU - Wang, Xuewen
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AU - Yuan, Yanling
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AU - Chen, Yanyin
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AU - Gu, Yaping
AU - Zhu, Laifeng
AU - Huang, Yaping
AU - Wang, Meijuan
AU - Wang, Yaping
AU - Shen, Ying
AU - Wu, Yindi
AU - Mao, Yanhua
AU - Cheng, Yinling
AU - Zhao, Chunjiang
AU - Sun, Yongli
AU - Zhu, Biqing
AU - Sun, Yulan
AU - Cai, Mingzheng
AU - Zhang, Yun
AU - Xue, Min
AU - Zhou, Yunfang
AU - Zhang, Ruhui
AU - Du, Yuping
AU - Li, Dongmei
AU - Ni, Yuxing
AU - Zhang, Lijun
AU - Zhong, Zhiqiong
AU - Zhu, Guoming
AU - Yu, Zhizhen
AU - Cao, Minhua
AU - Song, Zhongxian
AU - Xu, Jiali
AU - Tong, Zimei
AU - Gu, Peihua
AU - Agudelo, Julio Garzón
AU - Sussmann, Otto
AU - Mojica, Beatriz Eugenia
AU - Rojas, Catherine
AU - Beltran, Humberto
AU - Paez, Jerson
AU - Gómez, Wilmer Villamil
AU - Dajud, Luis
AU - Mendoza, Mariela
AU - Arrieta, Patrick
AU - Osorio, Laline
AU - Olarte, Narda
AU - Valderrama, Alberto
AU - Muñoz, Heidi Johanna
AU - Guzmán, Nayide Barahona
AU - Ferrer, Marena Rodríguez
AU - Villa, Guillermo Sarmiento
AU - Guzmán, Alfredo Lagares
AU - Linares, Claudia
AU - Cortés, Lorena Matta
AU - Campo, Luis Fernando Rendon
AU - Gómez, Wilmer Villamil
AU - Menco, Antonio
AU - Arrieta, Patrick
AU - Calderón, María Eugenia Rodríguez
AU - Parada, Dr Edwin Chapeta
AU - Fernandez, Ana María Pérez
AU - Martínez, Ivan Francisco Pinilla
AU - Saleg, Paula Andrea Martínez
AU - Vega, Yazmín León
AU - Luengas, Elkin Lemos
AU - Ramos, Carolina Romero
AU - Hernández, Herlidia Taboada
AU - Gomez, David Yepes
AU - Gomez, Bernarda Maria Vergara
AU - Ruiz, Marcel Gaviria
AU - Millán, Juan Carlos Torres
AU - López, Moisés Ulises Torres
AU - Parada, Edwin Chapeta
AU - Rochel, Andrés Eduardo Mindiola
AU - Hidalgo, Rosalía Fernández
AU - Calzada, Juan Manuel Aragón
AU - Muñoz, Gabriel
AU - Argüello, Adela Ruiz
AU - Chinchilla, Antonio Solano
AU - Fuentes, Carlos González
AU - Pérez, Clara Morales
AU - Pino, Osiel Requejo
AU - González, Orlando Delgado
AU - González, Dania Fernández
AU - de Wang, Carolina Martínez Rodríguez
AU - Severino, Ramona
AU - Tolari, Gilda
AU - Delgado, Margarita
AU - Vélez, Jorge Washington
AU - Zapata, Mario Alejandro Cadena
AU - Valle, Marcia Jacqueline
AU - Guayasamín, Silvia
AU - Seliem, Zeinab Salah
AU - El Kholy, Amani Ali
AU - Abdel-Aziz, Doaa
AU - Sabour, Muhamed Abd El
AU - Kalil, Mahmoud
AU - Saeed, Adel
AU - Gafarey, Maha El
AU - Fouad, Lamia
AU - Muhamed, Tamer
AU - Saeed, Hedya
AU - Casares, Ana Concepción Bran de
AU - Machuca, Lilian de Jesús
AU - Chaniotaki, Kalliopi
AU - Tsioutis, Constantinos
AU - Bampalis, Dimitris
AU - Gopinath, Ramachadran
AU - Ravindra, Nallagonda
AU - Karlekar, Anil
AU - Sood, Sanjeev
AU - Verma, Neeru
AU - Sen, Nagamani
AU - Subramani, Kandasamy
AU - Raj, John Prakash
AU - Mathur, Purva
AU - Kumar, Subodh
AU - Sahu, Samir
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AU - Jaggi, Namita
AU - Bhatnagar, Shaleen
AU - Myatra, Sheila Nainan
AU - Divatia,
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AU - Biswas, Sanjay
AU - Raut, Sandhya
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AU - Kumar, Rishi
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AU - Koppikar, Geeta
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AU - Jadhav, Shital
AU - Dwivedy, Arpita
AU - Shetty, Suvin
AU - Binu, Sheena
AU - Pawar, Mandakini
AU - Gupta, Amit
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AU - Kothari, Vatsal
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AU - Munshi, Nita
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AU - Dagys, Algirdas
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AU - Gómez, Ana Bertha Zavala
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AU - Gaytan, Jacobo Ayala
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AU - Martínez-Marroquín, Martha Yolanda
AU - Hernández, Andrés
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AU - Arteaga-Troncoso, Gabriel
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AU - Abidi, Khalid
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AU - Fakir, Ajaz
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AU - Jamil, Bushra
AU - Ali, Farheen
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AU - Bhutto, Gul Hassan
AU - Alfaro, Fernando G.
AU - Alvarado, Cecilia
AU - León, Luz Marina De
AU - Navarro, Rodolfo
AU - Moreno, José Luis
AU - Cerrad, Rigoberto
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AU - Goicochea, Iliana Paredes
AU - Sanchez, Abel Arroyo
AU - Alva, Guillermo Rios
AU - Ventura, Jorge García
AU - Aguilar, Miguel Ramírez
AU - Plasencia, Niler Segura
AU - Rodríguez, Teófilo
AU - Maldonado, Eduardo Fernández
AU - Espichan, Manuel Jesús Mayorga
AU - Echenique, Liliana
AU - Rosales, Rosa
AU - Bravo, Luis Isidro Castillo
AU - Cáceres, María Linares
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AU - López, Favio Sarmiento
AU - Saldarriaga, María Edelmira Cruz
AU - Morvelí, Eloy U.Villena
AU - Barriga, Herly
AU - Villacorta, Milena Sánchez
AU - Barrios, Sandro Castillo
AU - Zegarra, Socorro Liliana Torres
AU - Astete, Nazario Silva
AU - Guevara, Francisco Campos
AU - Mendoza, Carlos Bazan
AU - Ramírez, Augusto Valencia
AU - Pastrana, Javier Soto
AU - Wong, Fernando Martín Ramírez
AU - Ángeles, Carmen Saman
AU - Tavera, Zoila Díaz
AU - Ramirez, Eliza
AU - Vergara, Carlos Enrique La Hoz
AU - Mendoza, Liliana
AU - Sosa, Gladys Bonzano
AU - Chávez, Celene Manga
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AU - Astete, Nazario Silva
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AU - Jamulitrat, Silom
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AU - Ammar, Khaldi
AU - Öztürk, Recep
AU - Dikmen, Yalim
AU - Aygún, Gökhan
AU - Ulusoy, Sercan
AU - Arda, Bilgin
AU - Bacakoglu, Feza
AU - Sardan, Yesim Cetinkaya
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AU - Topeli, Arzu
AU - Akan, Özay Arıkan
AU - Tulunay, Melek
AU - Oral, Mehmet
AU - Ünal, Necmettin
AU - Alp, Emine
AU - Aygen, Bilgehan
AU - Sirmatel, Fatma
AU - Cengiz, Mustafa
AU - Yilmaz, Leyla
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AU - Turan, Gül Dem
AU - Akgün, Nur
AU - Ozdemir, Davut
AU - Guclu, Ertugrul
AU - Erdogan, Selvi
AU - Erben, Nurettin
AU - Ozgunes, Ilhan
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AU - Aygun, Canan
AU - Küçüködük, Sukru
AU - Arman, Dilek
AU - Hizel, Kenan
AU - Uzun, Cengiz
AU - Turgut, Huseyin
AU - Sacar, Suzan
AU - Sungurtekin, Hülya
AU - U�gurcan, Do�Gaç
AU - Koksal, Iftíhar
AU - Yýlmaz, Gürdal
AU - Kaya, Selçuk
AU - Ulusoy, Hülya
AU - Ersoz, Gulden
AU - Kaya, Ali
AU - Kuyucu, Necdet
AU - Esen, Saban
AU - Ulger, Fatma
AU - Dilek, Ahmet
AU - Yalcin, A. Nevzat
AU - Turhan, Ozge
AU - Keskin, Sevim
AU - Gumus, Eylul
AU - Dursun, Oguz
AU - Kendirli, Tanil
AU - Ince, Erdal
AU - Cliftci, Ergin
AU - Özdemir, Halil
AU - Demiroz, A. Pekcan
AU - Yetkin, M. Arzu
AU - Bulut, Cemal
AU - Erdinc, F. Sebnem
AU - Hatipoglu, Cigdem Ataman
AU - Erdinc, F. Sebnem
AU - Erbay, Ayse
AU - Willke, Ayse
AU - Meric, Meliha
AU - Azak, Emel
AU - Oncul, Oral
AU - Haznedaroglu, Tuncer
AU - Gorenek, Levent
AU - Acar, Ali
AU - Silvera, Eduardo
AU - Techera, Silvia
AU - Frachia, Adrián
AU - Algorta, Gabriela
AU - Gil de Añez, Zenaida Durán
AU - Bravo, Luis Montes
AU - Orozco, Nelva
AU - Mejías, Eugenia
AU - Trang, Dang Thi Van
AU - Nga, Thai Thi Kim
AU - Zruong, Pham Hông
PY - 2012/6/1
Y1 - 2012/6/1
N2 - The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia).
AB - The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia).
KW - Antibiotic resistance
KW - Bloodstream infection
KW - Catheter-associated urinary tract infection
KW - Central line-associated bloodstream infection
KW - Developing countries
KW - Device-associated infection
KW - Health care-associated infection
KW - Hospital infection
KW - Limited-resources countries
KW - Low-income countries
KW - Network
KW - Nosocomial infection
KW - Urinary tract infection
KW - Ventilator-associated pneumonia
UR - https://www.scopus.com/pages/publications/84861570184
U2 - 10.1016/j.ajic.2011.05.020
DO - 10.1016/j.ajic.2011.05.020
M3 - Article
AN - SCOPUS:84861570184
SN - 0196-6553
VL - 40
SP - 396
EP - 407
JO - American Journal of Infection Control
JF - American Journal of Infection Control
IS - 5
ER -