International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Atif Ali Hashmi, Syeda Narisa Iftikhar, Shahzeb Munawar, Omer Ahmed, Syed Rafay Yaqeen, Ishaq Azeem Asghar, Muhammad Irfan, Javaria Ali, Muhammad M. Edhi, Shumaila Kanwal Hashmi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalCancer Investigation
Volume40
Issue number3
DOIs
Publication statusPublished - 2022
Externally publishedYes

Keywords

  • Prostatic adenocarcinoma
  • cancer-specific survival
  • extraprostatic extension
  • gleason score
  • grade groups
  • perineural invasion

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