International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Atif Ali Hashmi; Syeda Narisa Iftikhar; Shahzeb Munawar; Omer Ahmed; Syed Rafay Yaqeen; Ishaq Azeem Asghar; Muhammad Irfan; Javaria Ali; Muhammad M. Edhi; Shumaila Kanwal Hashmi

doi:10.1080/07357907.2021.2019263

International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Atif Ali Hashmi
, Syeda Narisa Iftikhar
, Shahzeb Munawar
, Omer Ahmed
, Syed Rafay Yaqeen
, Ishaq Azeem Asghar
, Muhammad Irfan
, Javaria Ali
, Muhammad M. Edhi
, Shumaila Kanwal Hashmi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

Original language	English (UK)
Pages (from-to)	211-218
Number of pages	8
Journal	Cancer Investigation
Volume	40
Issue number	3
DOIs	https://doi.org/10.1080/07357907.2021.2019263
Publication status	Published - 2022
Externally published	Yes

Keywords

Prostatic adenocarcinoma
cancer-specific survival
extraprostatic extension
gleason score
grade groups
perineural invasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/07357907.2021.2019263

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@article{cfa7a65079fe41a3bb7ef0251d427a68,

title = "International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications",

abstract = "In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7\%) cases of grade group 1, 22 (12.8\%) grade group 2, 30 (17.4\%) grade group 3, 40 (23.3\%) grade group 4 and 53 (30.8\%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50\%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.",

keywords = "Prostatic adenocarcinoma, cancer-specific survival, extraprostatic extension, gleason score, grade groups, perineural invasion",

author = "Hashmi, \{Atif Ali\} and Iftikhar, \{Syeda Narisa\} and Shahzeb Munawar and Omer Ahmed and Yaqeen, \{Syed Rafay\} and Asghar, \{Ishaq Azeem\} and Muhammad Irfan and Javaria Ali and Edhi, \{Muhammad M.\} and Hashmi, \{Shumaila Kanwal\}",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor \& Francis Group, LLC.",

year = "2022",

doi = "10.1080/07357907.2021.2019263",

language = "English (UK)",

volume = "40",

pages = "211--218",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis Group LLC Philadelphia",

number = "3",

}

TY - JOUR

T1 - International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

AU - Hashmi, Atif Ali

AU - Iftikhar, Syeda Narisa

AU - Munawar, Shahzeb

AU - Ahmed, Omer

AU - Yaqeen, Syed Rafay

AU - Asghar, Ishaq Azeem

AU - Irfan, Muhammad

AU - Ali, Javaria

AU - Edhi, Muhammad M.

AU - Hashmi, Shumaila Kanwal

PY - 2022

Y1 - 2022

N2 - In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

AB - In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

KW - Prostatic adenocarcinoma

KW - cancer-specific survival

KW - extraprostatic extension

KW - gleason score

KW - grade groups

KW - perineural invasion

UR - https://www.scopus.com/pages/publications/85121784072

U2 - 10.1080/07357907.2021.2019263

DO - 10.1080/07357907.2021.2019263

M3 - Article

C2 - 34907822

AN - SCOPUS:85121784072

SN - 0735-7907

VL - 40

SP - 211

EP - 218

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -

International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Abstract

Keywords

UN SDGs

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