International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Atif Ali Hashmi; Syeda Narisa Iftikhar; Shahzeb Munawar; Omer Ahmed; Syed Rafay Yaqeen; Ishaq Azeem Asghar; Muhammad Irfan; Javaria Ali; Muhammad M. Edhi; Shumaila Kanwal Hashmi

doi:10.1080/07357907.2021.2019263

International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Atif Ali Hashmi, Syeda Narisa Iftikhar, Shahzeb Munawar, Omer Ahmed, Syed Rafay Yaqeen, Ishaq Azeem Asghar, Muhammad Irfan, Javaria Ali, Muhammad M. Edhi, Shumaila Kanwal Hashmi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

Original language	English (UK)
Pages (from-to)	211-218
Number of pages	8
Journal	Cancer Investigation
Volume	40
Issue number	3
DOIs	https://doi.org/10.1080/07357907.2021.2019263
Publication status	Published - 2022
Externally published	Yes

Keywords

Prostatic adenocarcinoma
cancer-specific survival
extraprostatic extension
gleason score
grade groups
perineural invasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/07357907.2021.2019263

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@article{cfa7a65079fe41a3bb7ef0251d427a68,

title = "International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications",

abstract = "In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7\%) cases of grade group 1, 22 (12.8\%) grade group 2, 30 (17.4\%) grade group 3, 40 (23.3\%) grade group 4 and 53 (30.8\%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50\%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.",

keywords = "Prostatic adenocarcinoma, cancer-specific survival, extraprostatic extension, gleason score, grade groups, perineural invasion",

author = "Hashmi, \{Atif Ali\} and Iftikhar, \{Syeda Narisa\} and Shahzeb Munawar and Omer Ahmed and Yaqeen, \{Syed Rafay\} and Asghar, \{Ishaq Azeem\} and Muhammad Irfan and Javaria Ali and Edhi, \{Muhammad M.\} and Hashmi, \{Shumaila Kanwal\}",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor \& Francis Group, LLC.",

year = "2022",

doi = "10.1080/07357907.2021.2019263",

language = "English (UK)",

volume = "40",

pages = "211--218",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis Group LLC Philadelphia",

number = "3",

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TY - JOUR

T1 - International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

AU - Hashmi, Atif Ali

AU - Iftikhar, Syeda Narisa

AU - Munawar, Shahzeb

AU - Ahmed, Omer

AU - Yaqeen, Syed Rafay

AU - Asghar, Ishaq Azeem

AU - Irfan, Muhammad

AU - Ali, Javaria

AU - Edhi, Muhammad M.

AU - Hashmi, Shumaila Kanwal

PY - 2022

Y1 - 2022

N2 - In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

AB - In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

KW - Prostatic adenocarcinoma

KW - cancer-specific survival

KW - extraprostatic extension

KW - gleason score

KW - grade groups

KW - perineural invasion

UR - https://www.scopus.com/pages/publications/85121784072

U2 - 10.1080/07357907.2021.2019263

DO - 10.1080/07357907.2021.2019263

M3 - Article

C2 - 34907822

AN - SCOPUS:85121784072

SN - 0735-7907

VL - 40

SP - 211

EP - 218

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -

International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Abstract

Keywords

UN SDGs

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