Intrahepatic cholestasis of pregnancy: Case series of a rare disease in an African setting

Davis Rubagumya, Miriam Mgonja, Munawar Kaguta, Ahmed Jusabani, Muzdalfat Abeid, Nancy Matillya

Research output: Contribution to journalArticlepeer-review


Intrahepatic cholestasis of pregnancy commonly presents in the second and third trimester with unexplained pruritus sine materia, abnormal liver function tests, and/or elevated serum total bile acid concentration. Its incidence ranges from less than 1% to 27.6%, with Araucana Indians from Chile being the highest affected. Intrahepatic cholestasis of pregnancy complicates pregnancy, hence influencing its outcomes. Our series involves three cases of pruritus in pregnancy ending with one elective cesarean delivery and two emergency cesarean deliveries without any significant complications to babies as well as immediate resolution of maternal symptoms. High index of suspicion for intrahepatic cholestasis of pregnancy is of paramount importance among clinicians even in primary care setup. Prompt treatment and intervention will prevent poor perinatal outcome.

Original languageEnglish
JournalSAGE Open Medical Case Reports
Publication statusPublished - 2022
Externally publishedYes


  • Intrahepatic cholestasis pregnancy
  • bile acids
  • pruritus


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