Intraperitoneal lignocaine (lidocaine) versus bupivacaine after laparoscopic cholecystectomy: Results of a randomized controlled trial

Muhammad Rizwan Khan, Rushna Raza, Syed Nabeel Zafar, Faisal Shamim, Syed Ahsan Raza, Khawaja Muhammad Inam Pal, Hasnain Zafar, Rehman Alvi, Tabish Chawla, Rizwan Azmi

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26 Citations (Scopus)


Background: Intraperitoneal local anesthetics have been shown to improve postoperative pain after laparoscopic cholecystectomy (LC). However, the choice of local anesthetic agent is debatable. We compared the analgesic efficacy of intraperitoneal lignocaine (lidocaine) versus bupivacaine after elective LC. Methods: We conducted a double-blind, randomized, controlled trial. We randomized consecutive patients undergoing LC into two groups. Group L received 10 mL 2% lignocaine (lidocaine), whereas Group B received 10 mL 0.5% bupivacaine, each diluted in 10 mL normal saline. All patients underwent standard perioperative anesthesia and analgesia protocol. We assessed patients at 0, 4, 8, 12, and 24 h postoperatively for pain using the visual analogue scale and verbal rating scale, and the need for additional analgesic medications. Results: We analyzed a total of 206 patients: 106 in Group L and 100 in Group B. Demographic details were similar between groups (P > 0.05). Abdominal pain decreased significantly with time in both groups, with a similar mean response profile (P < 0.001). There was no statistically significant difference between groups with regard to abdominal or shoulder pain by both visual analogue scale and verbal rating scale at all five time intervals (P > 0.05). There was also no significant difference in the side effect profile of both drugs (P > 0.05). A lower proportion of patients in Group B required additional narcotic analgesia (87%) compared with Group L (94%). This difference was marginally significant (P = 0.057). Conclusions: Bupivacaine and lignocaine (lidocaine) are both safe and equally effective at decreasing postoperative pain after LC.

Original languageEnglish
Pages (from-to)662-669
Number of pages8
JournalJournal of Surgical Research
Issue number2
Publication statusPublished - Dec 2012


  • Analgesia
  • Bupivacaine
  • Laparoscopic cholecystectomy
  • Lignocaine (lidocaine)
  • Postoperative


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