The e-Healthcare information offers unique security, privacy and confidentiality challenges that require a fresh examination of the mainstream concepts and approaches to information security. The significance of security and privacy in e-Healthcare information raised the issues of individual consent, confidentiality and privacy, which are the main determinants in adopting and successful utilising the e-Healthcare information. Current trends in the domain of e-Healthcare information management point to the need for comprehensive incorporation of security, privacy and confidentiality safeguards within the review of e-Healthcare information management frameworks and approaches. This raises major challenges that demands holistic approaches spanning a wide variety of legal, ethical, psychological, information and security engineering. This introductory chapter explores information security and challenges facing e-Healthcare information management.