Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates

S. Noordin, S. Shortkroff, C. B. Sledge, M. Spector

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Myriad molecular, cellular, and physiological processes underlie the inflammatory and osteolytic processes induced by particles of biomaterials resulting from the wear of implants such as total joint replacement prostheses. The objective this study was to investigate the role that the complement system may be playing in these phenomena. The aim was to evaluate the degree to which particles of selected orthopaedic materials - high density and ultrahigh molecular weight polyethylene, polymethylmethacrylate, and commercially pure titanium - cause the elevation of a key complement molecule, C3a, in an in vitro assay that directly measured the concentration of C3a. The results demonstrated that HDPE particles, at high concentration, are capable of causing the elevation of C3a in the in vitro assay. This finding is discussed in the context of other work and the mechanics of the complement system as it may affect the osteolytic process.

Original languageEnglish
Pages (from-to)5347-5352
Number of pages6
JournalBiomaterials
Volume25
Issue number23
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

Keywords

  • Biomaterials
  • Complement system
  • Orthopaedics
  • Osteolysis
  • Particles
  • Prostheses

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