TY - JOUR
T1 - Is migraine an MPV-related disease? An observational study of polish neurological patients
AU - Brzeźniakiewicz-Janus, Katarzyna
AU - Lancé, Marcus D.
AU - Tukiendorf, Andrzej
AU - Rupa-Matysek, Joanna
AU - Brzozowska-Mańkowska, Sybilla
AU - Franków, Mirosław
AU - Wolny-Rokicka, Edyta
AU - Gil, Lidia
N1 - Publisher Copyright:
© 2019 Katarzyna Brzeźniakiewicz-Janus et al.
PY - 2019
Y1 - 2019
N2 - Many studies have found correlations between abnormal MPV and clinical reactivity in a variety of diseases. In the present paper, we sought MPV-related neurological diseases that are less frequently reported in the literature. The electronic medical records of 852 neurological patients with mean platelet volume (MPV) measurements (F=45%, age=55.7±18.7, 8-104) were searched after the patients had received a diagnosis of a neurological disease (new and old episodes) according to the nine classes of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). A set of consecutive statistical methods (i.e., cluster analysis, segmented regression, linear correlation, propensity score matching, and mixed effects Poisson regression) were used to establish a link between MPV and neurological disease. A statistically significant (p<0.05) relationship with MPV was found only in pain syndrome patients, with seven out of eight clinically diagnosed migraine episodes. With all other ICD-10 classes of neurological diseases, the effect of MPV was found to be nonsignificant (p>0.05). MPV may implicate a clinical relationship with pain syndrome and migraine episodes. More complex statistics could help analyse data and find new correlations.
AB - Many studies have found correlations between abnormal MPV and clinical reactivity in a variety of diseases. In the present paper, we sought MPV-related neurological diseases that are less frequently reported in the literature. The electronic medical records of 852 neurological patients with mean platelet volume (MPV) measurements (F=45%, age=55.7±18.7, 8-104) were searched after the patients had received a diagnosis of a neurological disease (new and old episodes) according to the nine classes of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). A set of consecutive statistical methods (i.e., cluster analysis, segmented regression, linear correlation, propensity score matching, and mixed effects Poisson regression) were used to establish a link between MPV and neurological disease. A statistically significant (p<0.05) relationship with MPV was found only in pain syndrome patients, with seven out of eight clinically diagnosed migraine episodes. With all other ICD-10 classes of neurological diseases, the effect of MPV was found to be nonsignificant (p>0.05). MPV may implicate a clinical relationship with pain syndrome and migraine episodes. More complex statistics could help analyse data and find new correlations.
UR - http://www.scopus.com/inward/record.url?scp=85077119062&partnerID=8YFLogxK
U2 - 10.1155/2019/9454580
DO - 10.1155/2019/9454580
M3 - Article
C2 - 31885744
AN - SCOPUS:85077119062
SN - 0278-0240
VL - 2019
JO - Disease Markers
JF - Disease Markers
M1 - 9454580
ER -