Ischemic stroke in young Asian women: Risk factors, subtypes and outcome

Mohammad Wasay, Subhash Kaul, Bindu Menon, Narayanaswamy Venketasubramanian, Padma Gunaratne, Ahmed Khalifa, Niphon Poungvarin, Mohammad Saadatnia, Robert Ngo Gan, Alper Dai, M. M. Mehndiratta

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Background and Objective: The objective of our study was to describe risk factors, mechanisms and outcome of young Asian women with ischemic stroke. Methods: Twelve tertiary-care centers in 8 Asian countries participated. Women aged 15-45 years were included if they had an ischemic stroke supported by neuroimaging. Data on age, risk factor history, stroke mechanism and discharge status were collected. Results: A total of 958 subjects were included, their mean age was 34 years. Large-vessel thrombosis comprised 24%, cerebral venous thrombosis 21%, cardioembolism 19% and small-vessel thrombosis 15%. The stroke risk factors included hypertension (29%), diabetes (14%), pregnancy (11%), valvular heart disease (10%) and cigarette smoking (3%). Anemia was found in 42%, and mortality was 4%; at discharge, 17% had modified Rankin score (mRS) >4 and 83% mRS 0-3. Conclusion: Unlike among Caucasians, large-vessel thrombosis, cerebral venous thrombosis and cardioembolism are common among young Asian women with stroke. A high proportion are pregnancy-related. More studies are needed.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalCerebrovascular Diseases
Issue number4
Publication statusPublished - Sept 2010


  • Asian
  • Female
  • Outcome
  • Stroke
  • Women
  • Young


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