Job's syndrome with an atypical presentation

Abbas Ali Tasneem, Sabahat Sarfaraz, Syed Mujahid Hassan, Nasir Hassan Luck, Sabiha Anis, Zaigham Abbas

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1 Citation (Scopus)


Hyper Immunoglobulin E syndrome also called Job's or Buckley Syndrome is a rare primary immunodeficiency disease characterized by elevated serum IgE levels (>2000 IU/ml), recurrent infections and eosinophilia. Other features include coarse facies and non-immunologic abnormalities of the dentition, bones, vasculature and connective tissues. We are reporting a case of a twenty four years old male with coarse facies who presented with severe pallor and upper gastrointestinal bleeding. Investigations revealed markedly elevated serum IgE levels (11,800 IU/ml), severe anaemia, esophageoduodenal erosions, Helicobacter pylori (H. pylori) gastritis and oro-esophageal candidiasis.

Original languageEnglish
Pages (from-to)1427-1429
Number of pages3
JournalJournal of the Pakistan Medical Association
Issue number11
Publication statusPublished - Nov 2013
Externally publishedYes


  • H.pylori infection
  • Hyper IgE syndrome
  • Job's syndrome


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